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ABCB subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The ABCB subfamily is composed of four full transporters and two half transporters. This is the only human subfamily to have both half and full types of transporters. ABCB1 was discovered as a protein overexpressed in certain drug resistant tumor cells. It is expressed primarily in the blood brain barrier and liver and is thought to be involved in protecting cells from toxins. Cells that overexpress this protein exhibit multi-drug resistance [1,5].

Transporters

771
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MDR1, PGP1 (ABCB1) C Show summary » More detailed page go icon to follow link

TAP1 (ABCB2) C Show summary »

TAP2 (ABCB3) C Show summary » More detailed page go icon to follow link

PGY3 (ABCB4) C Show summary »


Target Id 771
Systematic nomenclature ABCB4
Common abbreviation PGY3
Previous and unofficial names P-glycoprotein 3 | GBD1 | MDR2 | MDR3 | PFIC-3 | PGY3 | ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2 | multidrug resistance protein 2 | multidrug resistance protein 3 | P-glycoprotein 2 | P-glycoprotein 3/ multidrug resistance 2 | Pgy2 | ATP-binding cassette, subfamily B (MDR/TAP), member 4 | ATP-binding cassette
Genes ABCB4 (Hs), Abcb4 (Mm), Abcb4 (Rn)
Ensembl ID ENSG00000005471 (Hs), ENSMUSG00000042476 (Mm), ENSRNOG00000029207 (Rn)
UniProtKB AC P21439 (Hs), P21440 (Mm), Q08201 (Rn)
Comment Transports phosphatidylcholine from intracellular to extracellular face of the hepatocyte canalicular membrane [15]. Heterozygous ABCB4 variants contribute to mild cholestatic phenotypes, while homozygous deficiency leads to Progressive Intrahepatic Familial Cholestasis (PFIC) Type 3, and increased risk of cholesterol gallstones [10].

ABCB5 C Show summary »

MTABC3 (ABCB6) C Show summary »

ABC7 (ABCB7) C Show summary »

MABC1 (ABCB8) C Show summary »

TAPL (ABCB9) C Show summary »

MTABC2 (ABCB10) C Show summary »

ABC16 (ABCB11) C Show summary »

References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.