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ABCB subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The ABCB subfamily is composed of four full transporters and two half transporters. This is the only human subfamily to have both half and full types of transporters. ABCB1 was discovered as a protein overexpressed in certain drug resistant tumor cells. It is expressed primarily in the blood brain barrier and liver and is thought to be involved in protecting cells from toxins. Cells that overexpress this protein exhibit multi-drug resistance [1,5].

Transporters

773
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MDR1, PGP1 (ABCB1) C Show summary » More detailed page go icon to follow link

TAP1 (ABCB2) C Show summary »

TAP2 (ABCB3) C Show summary » More detailed page go icon to follow link

PGY3 (ABCB4) C Show summary »

ABCB5 C Show summary »

MTABC3 (ABCB6) C Show summary »


Target Id 773
Systematic nomenclature ABCB6
Common abbreviation MTABC3
Previous and unofficial names Mitochondrial ABC transporter 3 | P-glycoprotein-related protein | ubiquitously expressed mammalian ABC half transporter | MTABC3 | umat | ATP-binding cassette half-transporter | ATP-binding cassette sub-family B member 6, mitochondrial | ATP-binding cassette, sub-family B (MDR/TAP), member 6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | ATP-binding cassette, subfamily B (MDR/TAP), member 6 | ATP-binding cassette
Genes ABCB6 (Hs), Abcb6 (Mm), Abcb6 (Rn)
Ensembl ID ENSG00000115657 (Hs), ENSMUSG00000026198 (Mm), ENSRNOG00000018697 (Rn)
UniProtKB AC Q9NP58 (Hs), Q9DC29 (Mm), O70595 (Rn)
Comment Putative mitochondrial porphyrin transporter [12]; other subcellular localizations are possible, such as the plasma membrane, as a specific determinant of the Langereis blood group system [9]. Loss of Abcb6 expression in mice leads to decreased expression and activity of CYP450 [4].

ABC7 (ABCB7) C Show summary »

MABC1 (ABCB8) C Show summary »

TAPL (ABCB9) C Show summary »

MTABC2 (ABCB10) C Show summary »

ABC16 (ABCB11) C Show summary »

References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.