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ABCB subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The ABCB subfamily is composed of four full transporters and two half transporters. This is the only human subfamily to have both half and full types of transporters. ABCB1 was discovered as a protein overexpressed in certain drug resistant tumor cells. It is expressed primarily in the blood brain barrier and liver and is thought to be involved in protecting cells from toxins. Cells that overexpress this protein exhibit multi-drug resistance [1,5].

Transporters

775
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MDR1, PGP1 (ABCB1) C Show summary » More detailed page go icon to follow link

TAP1 (ABCB2) C Show summary »

TAP2 (ABCB3) C Show summary » More detailed page go icon to follow link

PGY3 (ABCB4) C Show summary »

ABCB5 C Show summary »

MTABC3 (ABCB6) C Show summary »

ABC7 (ABCB7) C Show summary »

MABC1 (ABCB8) C Show summary »


Target Id 775
Systematic nomenclature ABCB8
Common abbreviation MABC1
Previous and unofficial names MABC1 | mitochondrial ABC protein | ABC transporter 8 | ATP-binding cassette sub-family B member 8, mitochondrial | ATP-binding cassette, sub-family B (MDR/TAP), member 8 | ATP-binding cassette, subfamily B (MDR/TAP), member 8 | ATP-binding cassette
Genes ABCB8 (Hs), Abcb8 (Mm), Abcb8 (Rn)
Ensembl ID ENSG00000197150 (Hs), ENSMUSG00000028973 (Mm), ENSRNOG00000008557 (Rn)
UniProtKB AC Q9NUT2 (Hs), Q9CXJ4 (Mm), Q5RKI8 (Rn)
Comment Mitochondrial; suggested to play a role in chemoresistance of melanoma [7]. Cardiac specific deletion of Abcb8 leads to cardiomyopathy and accumulation of mitochondrial iron, and is thus thought to modulate mitochondrial iron export [11].

TAPL (ABCB9) C Show summary »

MTABC2 (ABCB10) C Show summary »

ABC16 (ABCB11) C Show summary »

References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.