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ABCB subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The ABCB subfamily is composed of four full transporters and two half transporters. This is the only human subfamily to have both half and full types of transporters. ABCB1 was discovered as a protein overexpressed in certain drug resistant tumor cells. It is expressed primarily in the blood brain barrier and liver and is thought to be involved in protecting cells from toxins. Cells that overexpress this protein exhibit multi-drug resistance [1,5].

Transporters

777
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MDR1, PGP1 (ABCB1) C Show summary » More detailed page go icon to follow link

TAP1 (ABCB2) C Show summary »

TAP2 (ABCB3) C Show summary » More detailed page go icon to follow link

PGY3 (ABCB4) C Show summary »

ABCB5 C Show summary »

MTABC3 (ABCB6) C Show summary »

ABC7 (ABCB7) C Show summary »

MABC1 (ABCB8) C Show summary »

TAPL (ABCB9) C Show summary »

MTABC2 (ABCB10) C Show summary »


Target Id 777
Systematic nomenclature ABCB10
Common abbreviation MTABC2
Previous and unofficial names Mitochondrial ABC transporter 2 | M-ABC2 | MTABC2 | ABC transporter 10 protein | ATP-binding cassette, sub-family B (MDR/TAP), member 10 | ABC-me | ATP-binding cassette sub-family B member 10, mitochondrial | ATP-binding cassette, subfamily B (MDR/TAP), member 10 | ATP-binding cassette
Genes ABCB10 (Hs), Abcb10 (Mm), Abcb10 (Rn)
Ensembl ID ENSG00000135776 (Hs), ENSMUSG00000031974 (Mm), ENSRNOG00000017993 (Rn)
UniProtKB AC Q9NRK6 (Hs), Q9JI39 (Mm)
Comment Mitochondrial location; the first human ABC transporter to have a crystal structure reported [19]. ABCB10 is important in early steps of heme synthesis in the heart and is required for normal red blood cell development [2,21].

ABC16 (ABCB11) C Show summary »

References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.