Top ▲

P2A P-type ATPases: Ca2+-ATPases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


Click here for help

« Hide

The sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA) is an intracellular membrane-associated pump for sequestering calcium from the cytosol into intracellular organelles, usually associated with the recovery phase following excitation of muscle and nerves.

The plasma membrane Ca2+-ATPase (PMCA) is a cell-surface pump for extruding calcium from the cytosol, usually associated with the recovery phase following excitation of cells. The active pump is a homodimer, each subunit of which is made up of ten TM segments, with cytosolic C- and N-termini and two large intracellular loops.

Secretory pathway Ca2+-ATPases (SPCA) allow accumulation of calcium and manganese in the Golgi apparatus.


Click here for help

SERCA1 Show summary »

Target Id 840
Nomenclature SERCA1
Previous and unofficial names Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | ATP2A | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 | calcium pump 1 | endoplasmic reticulum class 1/2 Ca(2+) ATPase | SR Ca(2+)-ATPase 1 | ATPase, Ca� transporting, cardiac muscle, fast twitch 1 | ATPase
Genes ATP2A1 (Hs), Atp2a1 (Mm), Atp2a1 (Rn)
Ensembl ID ENSG00000196296 (Hs), ENSMUSG00000030730 (Mm)
UniProtKB AC O14983 (Hs), Q8R429 (Mm), Q64578 (Rn)
EC number
Allosteric modulators
TGN4 (Negative) pIC50 8.9 [5]

SERCA2 Show summary »

SERCA3 Show summary »


Click here for help

Show »


Click here for help

Show »

How to cite this family page

Database page citation:

P2A P-type ATPases: Ca2+-ATPases. Accessed on 09/12/2022. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.