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P2A P-type ATPases: Ca2+-ATPases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA) is an intracellular membrane-associated pump for sequestering calcium from the cytosol into intracellular organelles, usually associated with the recovery phase following excitation of muscle and nerves.

The plasma membrane Ca2+-ATPase (PMCA) is a cell-surface pump for extruding calcium from the cytosol, usually associated with the recovery phase following excitation of cells. The active pump is a homodimer, each subunit of which is made up of ten TM segments, with cytosolic C- and N-termini and two large intracellular loops.

Secretory pathway Ca2+-ATPases (SPCA) allow accumulation of calcium and manganese in the Golgi apparatus.

Transporters

841
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Target Id 841
Nomenclature SERCA2
Previous and unofficial names calcium pump 2 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | ATP2B | DAR | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2  | SercaII | endoplasmic reticulum class 1/2 Ca(2+) ATPase | sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase 2 | SR Ca(2+)-ATPase 2 | sarco/endoplasmic reticulum Ca2+-ATPase 2 | SERCA2B | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | ATPase, Ca� transporting, cardiac muscle, slow twitch 2 | ATPase
Genes ATP2A2 (Hs), Atp2a2 (Mm), Atp2a2 (Rn)
Ensembl ID ENSG00000174437 (Hs), ENSMUSG00000029467 (Mm), ENSRNOG00000001285 (Rn)
UniProtKB AC P16615 (Hs), O55143 (Mm), P11507 (Rn)
EC number
3.6.3.8

SERCA3 Show summary »

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How to cite this family page

Database page citation:

P2A P-type ATPases: Ca2+-ATPases. Accessed on 29/02/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=159.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.