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Class I transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Class I transporters are able to transport D-glucose, but not D-fructose, in the direction of the concentration gradient and may be inhibited non-selectively by phloretin and . GLUT1 is the major glucose transporter in brain, placenta and erythrocytes, GLUT2 is found in the pancreas, liver and kidneys, GLUT3 is neuronal and placental, while GLUT4 is the insulin-responsive transporter found in skeletal muscle, heart and adipose tissue. GLUT14 appears to result from gene duplication of GLUT3 and is expressed in the testes [3].

Transporters

GLUT1 (Glucose transporter 1 / SLC2A1) C Show summary » More detailed page

GLUT2 (Glucose transporter 2 / SLC2A2) C Show summary »

GLUT3 (Glucose transporter 3 / SLC2A3) C Show summary »

GLUT4 (Glucose transporter 4 / SLC2A4) C Show summary »

GLUT14 (Glucose transporter 14 / SLC2A14) C Show summary »

References

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How to cite this family page

Database page citation:

Class I transporters. Accessed on 17/02/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=165.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Transporters. Br J Pharmacol. 174 Suppl 1: S360-S446.