Class I transporters | Transporters | IUPHAR/BPS Guide to PHARMACOLOGY

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Class I transporters

Class I transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Class I transporters are able to transport D-glucose, but not D-fructose, in the direction of the concentration gradient and may be inhibited non-selectively by phloretin and . GLUT1 is the major glucose transporter in brain, placenta and erythrocytes, GLUT2 is found in the pancreas, liver and kidneys, GLUT3 is neuronal and placental, while GLUT4 is the insulin-responsive transporter found in skeletal muscle, heart and adipose tissue. GLUT14 appears to result from gene duplication of GLUT3 and is expressed in the testes [3].

Transporters

GLUT1 (Glucose transporter 1 / SLC2A1) C Show summary »« Hide summary More detailed page

Target Id

875

Nomenclature

Glucose transporter 1

Systematic nomenclature

SLC2A1

Common abbreviation

GLUT1

Previous and unofficial names

Genes

SLC2A1 (Hs), Slc2a1 (Mm), Slc2a1 (Rn)

Ensembl ID

ENSG00000117394 (Hs), ENSMUSG00000028645 (Mm), ENSRNOG00000007284 (Rn)

UniProtKB AC

P11166 (Hs), P17809 (Mm), P11167 (Rn)

Bioparadigms SLC Tables

SLC2A1 (Hs)

Substrates

D-glucosamine (D-glucose = D-glucosamine ) [2]

D-glucose (D-glucose = D-glucosamine ) [2]

dehydroascorbic acid [1]

Labelled ligands

[³H]2-deoxyglucose

Comment

GLUT1 is a class I facilitative sugar transporter. GLUT1 functions to maintain basal glucose import which is required for cellular respiration.

GLUT2 (Glucose transporter 2 / SLC2A2) C Show summary »« Hide summary

Target Id

876

Nomenclature

Glucose transporter 2

Systematic nomenclature

SLC2A2

Common abbreviation

GLUT2

Previous and unofficial names

Genes

SLC2A2 (Hs), Slc2a2 (Mm), Slc2a2 (Rn)

Ensembl ID

ENSG00000163581 (Hs), ENSMUSG00000027690 (Mm), ENSRNOG00000011875 (Rn)

UniProtKB AC

P11168 (Hs), P14246 (Mm), P12336 (Rn)

Bioparadigms SLC Tables

SLC2A2 (Hs)

Substrates

D-glucosamine (D-glucosamine > D-glucose) [2]

D-glucose (D-glucosamine > D-glucose) [2]

Labelled ligands

[³H]2-deoxyglucose

GLUT3 (Glucose transporter 3 / SLC2A3) C Show summary »« Hide summary

Target Id

877

Nomenclature

Glucose transporter 3

Systematic nomenclature

SLC2A3

Common abbreviation

GLUT3

Previous and unofficial names

Genes

SLC2A3 (Hs), Slc2a3 (Mm), Slc2a3 (Rn)

Ensembl ID

ENSG00000059804 (Hs), ENSMUSG00000003153 (Mm), ENSRNOG00000008376 (Rn)

UniProtKB AC

P11169 (Hs), P32037 (Mm), Q07647 (Rn)

Bioparadigms SLC Tables

SLC2A3 (Hs)

Substrates

D-glucose

Labelled ligands

[³H]2-deoxyglucose

GLUT4 (Glucose transporter 4 / SLC2A4) C Show summary »« Hide summary

Target Id

878

Nomenclature

Glucose transporter 4

Systematic nomenclature

SLC2A4

Common abbreviation

GLUT4

Previous and unofficial names

Insulin-responsive glucose transporter | Glucose transporter 4 insuline-responsive | solute carrier family 2 member 4 | solute carrier family 2 (facilitated glucose transporter) member 4 | GLUT4 | solute carrier family 2 (facilitated glucose transporter), member 4 | solute carrier family 2 (facilitated glucose transporter)

Genes

SLC2A4 (Hs), Slc2a4 (Mm), Slc2a4 (Rn)

Ensembl ID

ENSG00000181856 (Hs), ENSMUSG00000018566 (Mm), ENSRNOG00000017226 (Rn)

UniProtKB AC

P14672 (Hs), P14142 (Mm), P19357 (Rn)

Bioparadigms SLC Tables

SLC2A4 (Hs)

Substrates

D-glucosamine (D-glucosamine ≥ D-glucose) [2]

D-glucose (D-glucosamine ≥ D-glucose) [2]

Labelled ligands

[³H]2-deoxyglucose

GLUT14 (Glucose transporter 14 / SLC2A14) C Show summary »« Hide summary

Target Id	879
Nomenclature	Glucose transporter 14
Systematic nomenclature	SLC2A14
Common abbreviation	GLUT14
Previous and unofficial names	GLUT14 \| SLC2A3P3 \| solute carrier family 2 (facilitated glucose transporter), member 3 pseudogene 3 \| solute carrier family 2 (facilitated glucose transporter), member 14
Genes	SLC2A14 (Hs)
Ensembl ID	ENSG00000173262 (Hs)
UniProtKB AC	Q8TDB8 (Hs)
Bioparadigms SLC Tables	SLC2A14 (Hs)

References

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1. Bianchi J, Rose RC. (1986) Glucose-independent transport of dehydroascorbic acid in human erythrocytes. Proc. Soc. Exp. Biol. Med., 181 (3): 333-7. [PMID:3945643]

2. Uldry M, Ibberson M, Hosokawa M, Thorens B. (2002) GLUT2 is a high affinity glucosamine transporter. FEBS Lett., 524 (1-3): 199-203. [PMID:12135767]

3. Wu X, Freeze HH. (2002) GLUT14, a duplicon of GLUT3, is specifically expressed in testis as alternative splice forms. Genomics, 80 (6): 553-7. [PMID:12504846]

How to cite this family page

Database page citation:

Class I transporters. Accessed on 22/02/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=165.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Transporters. Br J Pharmacol. 174 Suppl 1: S360-S446.