Top ▲

Class I transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide

Class I transporters are able to transport D-glucose, but not D-fructose, in the direction of the concentration gradient and may be inhibited non-selectively by phloretin and cytochalasin B. GLUT1 is the major glucose transporter in brain, placenta and erythrocytes, GLUT2 is found in the pancreas, liver and kidneys, GLUT3 is neuronal and placental, while GLUT4 is the insulin-responsive transporter found in skeletal muscle, heart and adipose tissue. GLUT14 appears to result from gene duplication of GLUT3 and is expressed in the testes [3].

Transporters

877
Click here for help

GLUT1 (Glucose transporter 1 / SLC2A1) C Show summary » More detailed page go icon to follow link

GLUT2 (Glucose transporter 2 / SLC2A2) C Show summary »

GLUT3 (Glucose transporter 3 / SLC2A3) C Show summary »


Target Id 877
Nomenclature Glucose transporter 3
Systematic nomenclature SLC2A3
Common abbreviation GLUT3
Previous and unofficial names brain glucose transporter | Fructose transporter | GLUT3 | glucose transporter type 3, brain | Solute carrier family 2 A3 (neuron glucose transporter) | solute carrier family 2, facilitated glucose transporter member 3 | solute carrier family 2, member 2 | solute carrier family 2, member 3 | solute carrier family 2 (facilitated glucose transporter), member 3 | solute carrier family 2 (facilitated glucose transporter)
Genes SLC2A3 (Hs), Slc2a3 (Mm), Slc2a3 (Rn)
Ensembl ID ENSG00000059804 (Hs), ENSMUSG00000003153 (Mm), ENSRNOG00000008376 (Rn)
UniProtKB AC P11169 (Hs), P32037 (Mm), Q07647 (Rn)
Bioparadigms SLC Tables SLC2A3 (Hs)
Substrates
D-glucose
Labelled ligands
[3H]2-deoxyglucose

GLUT4 (Glucose transporter 4 / SLC2A4) C Show summary »

GLUT14 (Glucose transporter 14 / SLC2A14) C Show summary »

References

Click here for help

Show »

How to cite this family page

Database page citation:

Class I transporters. Accessed on 24/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=165.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.