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Sodium myo-inositol cotransporter transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Three different mammalian myo-inositol cotransporters are currently known; two are the Na+-coupled SMIT1 and SMIT2 tabulated below and the third is proton-coupled HMIT (SLC2A13). SMIT1 and SMIT2 have a widespread and overlapping tissue location but in polarized cells, such as the Madin-Darby canine kidney cell line, they segregate to the basolateral and apical membranes, respectively [2]. In the nephron, SMIT1 mediates myo-inositol uptake as a ‘compatible osmolyte’ when inner medullary tubules are exposed to increases in extracellular osmolality, whilst SMIT2 mediates the reabsorption of myo-inositol from the filtrate. In some species (e.g. rat, but not rabbit) apically located SMIT2 is responsible for the uptake of myo-inositol from the intestinal lumen [1].

Transporters

924
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SMIT1 (SMIT / SLC5A3) C Show summary »


Target Id 924
Nomenclature SMIT
Systematic nomenclature SLC5A3
Common abbreviation SMIT1
Previous and unofficial names Sodium/myo-inositol cotransporter (SMIT) | solute carrier family 5 (inositol transporter), member 3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | solute carrier family 5 (inositol transporters)
Genes SLC5A3 (Hs), Slc5a3 (Mm), Slc5a3 (Rn)
Ensembl ID ENSG00000198743 (Hs), ENSMUSG00000089774 (Mm), ENSRNOG00000067988 (Rn)
UniProtKB AC P53794 (Hs), Q9JKZ2 (Mm)
Bioparadigms SLC Tables SLC5A3 (Hs)
RESOLUTE SLC5A3 (Hs)
Substrates myo-inositol, scyllo-inositol > L-fucose > L-xylose > L-glucose, D-glucose, α-MDG > D-galactose, D-fucose > D-xylose  [5]
Inhibitors
phlorizin [4]
Stoichiometry 2 Na+ :1 myo-inositol [5]

SMIT2 (SGLT6 / SLC5A11) C Show summary »

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How to cite this family page

Database page citation:

Sodium myo-inositol cotransporter transporters. Accessed on 30/01/2023. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=175.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.