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Sodium myo-inositol cotransporter transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Three different mammalian myo-inositol cotransporters are currently known; two are the Na+-coupled SMIT1 and SMIT2 tabulated below and the third is proton-coupled HMIT (SLC2A13). SMIT1 and SMIT2 have a widespread and overlapping tissue location but in polarized cells, such as the Madin-Darby canine kidney cell line, they segregate to the basolateral and apical membranes, respectively [2]. In the nephron, SMIT1 mediates myo-inositol uptake as a ‘compatible osmolyte’ when inner medullary tubules are exposed to increases in extracellular osmolality, whilst SMIT2 mediates the reabsorption of myo-inositol from the filtrate. In some species (e.g. rat, but not rabbit) apically located SMIT2 is responsible for the uptake of myo-inositol from the intestinal lumen [1].

Transporters

925
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SMIT1 (SMIT / SLC5A3) C Show summary »

SMIT2 (SGLT6 / SLC5A11) C Show summary »


Target Id 925
Nomenclature SGLT6
Systematic nomenclature SLC5A11
Common abbreviation SMIT2
Previous and unofficial names kST1 | sodium/glucose cotransporter6 | Na(+)/myo-inositol cotransporter 2 | sodium/glucose cotransporter KST1 | sodium/myo-inositol cotransporter 2 | sodium-dependent glucose cotransporter | solute carrier family 5 member 11 | solute carrier family 5 (sodium/glucose cotransporter), member 11 | solute carrier family 5 (sodium/inositol cotransporter), member 11 | solute carrier family 5 (sodium/glucose cotransporter)
Genes SLC5A11 (Hs), Slc5a11 (Mm), Slc5a11 (Rn)
Ensembl ID ENSG00000158865 (Hs), ENSMUSG00000030769 (Mm), ENSRNOG00000013407 (Rn)
UniProtKB AC Q8WWX8 (Hs), Q8K0E3 (Mm), Q9Z1F2 (Rn)
Bioparadigms SLC Tables SLC5A11 (Hs)
Substrates myo-inositol = D-chiro-inositol> D-glucose > D-xylose > L-xylose  [4]
Inhibitors
phlorizin pKi 4.1 [4]
Stoichiometry 2 Na+ :1 myo-inositol [3]

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References

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How to cite this family page

Database page citation:

Sodium myo-inositol cotransporter transporters. Accessed on 18/01/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=175.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.