Top ▲

SLC8 family of sodium/calcium exchangers C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


Click here for help

« Hide

The sodium/calcium exchangers (NCX) use the extracellular sodium concentration to facilitate the extrusion of calcium out of the cell. Alongside the plasma membrane Ca2+-ATPase (PMCA) and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA), as well as the sodium/potassium/calcium exchangers (NKCX, SLC24 family), NCX allow recovery of intracellular calcium back to basal levels after cellular stimulation. When intracellular sodium ion levels rise, for example, following depolarisation, these transporters can operate in the reverse direction to allow calcium influx and sodium efflux, as an electrogenic mechanism. Structural modelling suggests the presence of 9 TM segments, with a large intracellular loop between the fifth and sixth TM segments [1].


Click here for help

NCX1 (Sodium/calcium exchanger 1 / SLC8A1) C Show summary »

Target Id 945
Nomenclature Sodium/calcium exchanger 1
Systematic nomenclature SLC8A1
Common abbreviation NCX1
Previous and unofficial names Na+/Ca++ exchanger | Na(+)/Ca(2+)-exchange protein 1 | Na-Ca exchanger | Ncx | solute carrier family 8 (sodium/calcium exchanger) member 1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | solute carrier family 8 (sodium/calcium exchanger)
Genes SLC8A1 (Hs), Slc8a1 (Mm), Slc8a1 (Rn)
Ensembl ID ENSG00000183023 (Hs), ENSMUSG00000054640 (Mm), ENSRNOG00000008479 (Rn)
UniProtKB AC P32418 (Hs), P70414 (Mm), Q01728 (Rn)
Bioparadigms SLC Tables SLC8A1 (Hs)
neurounina-1 pEC50 8.9 [6] - Dog
Stoichiometry 3 Na+ (in) : 1 Ca2+ (out) or 4 Na+ (in) : 1 Ca2+ (out) [2]; Reverse mode 1 Ca2+ (in): 1 Na+ (out)

NCX2 (Sodium/calcium exchanger 2 / SLC8A2) C Show summary »

NCX3 (Sodium/calcium exchanger 3 / SLC8A3) C Show summary »


Click here for help

Show »

Further reading

Click here for help

Show »


Click here for help

Show »

NC-IUPHAR subcommittee and family contributors

Show »

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.