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SLC8 family of sodium/calcium exchangers C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The sodium/calcium exchangers (NCX) use the extracellular sodium concentration to facilitate the extrusion of calcium out of the cell. Alongside the plasma membrane Ca2+-ATPase (PMCA) and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA), as well as the sodium/potassium/calcium exchangers (NKCX, SLC24 family), NCX allow recovery of intracellular calcium back to basal levels after cellular stimulation. When intracellular sodium ion levels rise, for example, following depolarisation, these transporters can operate in the reverse direction to allow calcium influx and sodium efflux, as an electrogenic mechanism. Structural modelling suggests the presence of 9 TM segments, with a large intracellular loop between the fifth and sixth TM segments [1].

Transporters

946
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NCX1 (Sodium/calcium exchanger 1 / SLC8A1) C Show summary »

NCX2 (Sodium/calcium exchanger 2 / SLC8A2) C Show summary »


Target Id 946
Nomenclature Sodium/calcium exchanger 2
Systematic nomenclature SLC8A2
Common abbreviation NCX2
Previous and unofficial names Na(+)/Ca(2+)-exchange protein 2 | solute carrier family 8 (sodium/calcium exchanger), member 2 | solute carrier family 8 (sodium/calcium exchanger)
Genes SLC8A2 (Hs), Slc8a2 (Mm), Slc8a2 (Rn)
Ensembl ID ENSG00000118160 (Hs), ENSMUSG00000030376 (Mm), ENSRNOG00000001492 (Rn)
UniProtKB AC Q9UPR5 (Hs), P48768 (Rn)
Bioparadigms SLC Tables SLC8A2 (Hs)
RESOLUTE SLC8A2 (Hs)
Activators
neurounina-1 pEC50 8.8 [6] - Rat

NCX3 (Sodium/calcium exchanger 3 / SLC8A3) C Show summary »

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Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.