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SLC9 family of sodium/hydrogen exchangers C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Sodium/hydrogen exchangers or sodium/proton antiports are a family of transporters that maintain cellular pH by utilising the sodium gradient across the plasma membrane to extrude protons produced by metabolism, in a stoichiometry of 1 Na+ (in) : 1 H+ (out). Several isoforms, NHE6, NHE7, NHE8 and NHE9 appear to locate on intracellular membranes [5-7]. Li+ and NH4+, but not K+, ions may also be transported by some isoforms. Modelling of the topology of these transporters indicates 12 TM regions with an extended intracellular C-terminus containing multiple regulatory sites.

NHE1 is considered to be a ubiquitously-expressed ‘housekeeping’ transporter. NHE3 is highly expressed in the intestine and kidneys and regulate sodium movements in those tissues. NHE10 is present in sperm [10] and osteoclasts [3]; gene disruption results in infertile male mice [10].

Transporters

950
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NHE1 (Sodium/hydrogen exchanger 1 / SLC9A1) Show summary »

NHE2 (Sodium/hydrogen exchanger 2 / SLC9A2) Show summary »

NHE3 (Sodium/hydrogen exchanger 3 / SLC9A3) Show summary »


Target Id 950
Nomenclature Sodium/hydrogen exchanger 3
Systematic nomenclature SLC9A3
Common abbreviation NHE3
Previous and unofficial names Na(+)/H(+) exchanger 3 | plasma membrane ion transport protein | Solute carrier family 9 (sodium/hydrogen exchanger 3) antiporter 3 Na+/H+ (amiloride insensitive) | solute carrier family 9 member 3 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 | solute carrier family 9 (sodium/hydrogen exchanger)
Genes SLC9A3 (Hs), Slc9a3 (Mm), Slc9a3 (Rn)
Ensembl ID ENSG00000066230 (Hs), ENSMUSG00000036123 (Mm), ENSRNOG00000015159 (Rn)
UniProtKB AC P48764 (Hs), P26433 (Rn)
Bioparadigms SLC Tables SLC9A3 (Hs)
Inhibitors
amiloride pKi <4.0 [4] - Rat
tenapanor pIC50 >7.0 [1] - Rat

NHE4 (Sodium/hydrogen exchanger 4 / SLC9A4) Show summary »

NHE5 (Sodium/hydrogen exchanger 5 / SLC9A5) Show summary »

NHE6 (Sodium/hydrogen exchanger 6 / SLC9A6) Show summary »

NHE7 (Sodium/hydrogen exchanger 7 / SLC9A7) Show summary »

NHE8 (Sodium/hydrogen exchanger 8 / SLC9A8) Show summary »

NHE9 (Sodium/hydrogen exchanger 9 / SLC9A9) Show summary »

NHA1 (solute carrier family 9 member B1 / SLC9B1) Show summary »

NHA2 (solute carrier family 9 member B2 / SLC9B2) Show summary »

Sperm-NHE (Sodium/hydrogen exchanger 10 / SLC9C1) Show summary »

NHE11 (Sodium/hydrogen exchanger 11 / SLC9C2) Show summary »

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Further reading

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References

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How to cite this family page

Database page citation:

SLC9 family of sodium/hydrogen exchangers. Accessed on 20/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=181.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.