Top ▲

SLC9 family of sodium/hydrogen exchangers C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide

Sodium/hydrogen exchangers or sodium/proton antiports are a family of transporters that maintain cellular pH by utilising the sodium gradient across the plasma membrane to extrude protons produced by metabolism, in a stoichiometry of 1 Na+ (in) : 1 H+ (out). Several isoforms, NHE6, NHE7, NHE8 and NHE9 appear to locate on intracellular membranes [5-7]. Li+ and NH4+, but not K+, ions may also be transported by some isoforms. Modelling of the topology of these transporters indicates 12 TM regions with an extended intracellular C-terminus containing multiple regulatory sites.

NHE1 is considered to be a ubiquitously-expressed ‘housekeeping’ transporter. NHE3 is highly expressed in the intestine and kidneys and regulate sodium movements in those tissues. NHE10 is present in sperm [10] and osteoclasts [3]; gene disruption results in infertile male mice [10].

Transporters

957
Click here for help

NHE1 (Sodium/hydrogen exchanger 1 / SLC9A1) Show summary »

NHE2 (Sodium/hydrogen exchanger 2 / SLC9A2) Show summary »

NHE3 (Sodium/hydrogen exchanger 3 / SLC9A3) Show summary »

NHE4 (Sodium/hydrogen exchanger 4 / SLC9A4) Show summary »

NHE5 (Sodium/hydrogen exchanger 5 / SLC9A5) Show summary »

NHE6 (Sodium/hydrogen exchanger 6 / SLC9A6) Show summary »

NHE7 (Sodium/hydrogen exchanger 7 / SLC9A7) Show summary »

NHE8 (Sodium/hydrogen exchanger 8 / SLC9A8) Show summary »

NHE9 (Sodium/hydrogen exchanger 9 / SLC9A9) Show summary »

NHA1 (solute carrier family 9 member B1 / SLC9B1) Show summary »

NHA2 (solute carrier family 9 member B2 / SLC9B2) Show summary »

Sperm-NHE (Sodium/hydrogen exchanger 10 / SLC9C1) Show summary »


Target Id 957
Nomenclature Sodium/hydrogen exchanger 10
Systematic nomenclature SLC9C1
Common abbreviation Sperm-NHE
Previous and unofficial names sNHE | Sperm-specific Na+/H+ exchanger | SLC9A10 | sperm-NHE | solute carrier family 9, isoform 10 | sperm-specific sodium proton exchanger | spermNHE | solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1 | solute carrier family 9, subfamily C (Na+transporting carboxylic acid decarboxylase), member 1 | solute carrier family 9
Genes SLC9C1 (Hs), Slc9c1 (Mm), Slc9c1 (Rn)
Ensembl ID ENSG00000172139 (Hs), ENSMUSG00000033210 (Mm), ENSRNOG00000022007 (Rn)
UniProtKB AC Q4G0N8 (Hs), Q6UJY2 (Mm)
Bioparadigms SLC Tables SLC9C1 (Hs)
RESOLUTE SLC9C1 (Hs)

NHE11 (Sodium/hydrogen exchanger 11 / SLC9C2) Show summary »

Comments

Click here for help

Show »

Further reading

Click here for help

Show »

References

Click here for help

Show »

How to cite this family page

Database page citation:

SLC9 family of sodium/hydrogen exchangers. Accessed on 08/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=181.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.