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SLC10 family of sodium-bile acid co-transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The SLC10 family transport bile acids, sulphated solutes, and other xenobiotics in a sodium-dependent manner. The founding members, SLC10A1 (NTCP) and SLC10A2 (ASBT) function, along with members of the ABC transporter family (MDR1/ABCB1, BSEP/ABCB11 and MRP2/ABCC2) and the organic solute transporter obligate heterodimer OSTα:OSTβ (SLC51), to maintain the enterohepatic circulation of bile acids [5,17]. SLC10A6 (SOAT) functions as a sodium-dependent transporter of sulphated solutes including sulfphated steroids and bile acids [8,10]. Transport function has not yet been demonstrated for the 4 remaining members of the SLC10 family, SLC10A3 (P3), SLC10A4 (P4), SLC10A5 (P5), and SLC10A7 (P7), and the identity of their endogenous substrates remain unknown [7,10,13,20]. Members of the SLC10 family are predicted to have seven transmembrane domains with an extracellular N-terminus and cytoplasmic C-terminus [1,14].

Transporters

959
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NTCP (Sodium/bile acid and sulphated solute cotransporter 1 / SLC10A1) C Show summary »


Target Id 959
Nomenclature Sodium/bile acid and sulphated solute cotransporter 1
Systematic nomenclature SLC10A1
Common abbreviation NTCP
Previous and unofficial names liver sodium/bile acid cotransporter | Na+-taurocholate cotransporing polypeptide | sodium bile acid cotransporting polypeptide | solute carrier family 10 (sodium/bile acid cotransporter family), member 1 | solute carrier family 10 (sodium/bile acid cotransporter), member 1 | solute carrier family 10 (sodium/bile acid cotransporter family)
Genes SLC10A1 (Hs), Slc10a1 (Mm), Slc10a1 (Rn)
Ensembl ID ENSG00000100652 (Hs), ENSMUSG00000021135 (Mm), ENSRNOG00000005794 (Rn)
UniProtKB AC Q14973 (Hs), O08705 (Mm), P26435 (Rn)
Bioparadigms SLC Tables SLC10A1 (Hs)
Endogenous substrates tauroursodeoxycholic acid, taurocholic acid, taurochenodeoxycholic acid > glycocholic acid > cholic acid  [18]
Endogenous substrates
dehydroepiandrosterone sulphate [4,7,18]
estrone-3-sulphate
iodothyronine sulphates [20]
Inhibitors
cyclosporin A pKi 5.1 [6]
irbesartan pKi 4.9 [6]
(-)-propranolol pIC50 8.2 [16]
cyclosporin A pIC50 6.0 [16]
(+)-propranolol pIC50 5.3 [16]
Stoichiometry 2 Na+: 1 bile acid [1,8]

ASBT (Sodium/bile acid and sulphated solute cotransporter 2 / SLC10A2) C Show summary »

P3 (Sodium/bile acid and sulphated solute cotransporter 3 / SLC10A3) Show summary »

P4 (Sodium/bile acid and sulphated solute cotransporter 4 / SLC10A4) Show summary »

P5 (Sodium/bile acid and sulphated solute cotransporter 5 / SLC10A5) Show summary »

SOAT (Sodium/bile acid and sulphated solute cotransporter 6 / SLC10A6) C Show summary »

P7 (Sodium/bile acid and sulphated solute cotransporter 7 / SLC10A7) Show summary »

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How to cite this family page

Database page citation:

SLC10 family of sodium-bile acid co-transporters. Accessed on 28/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=182.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.