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SLC12 family of cation-coupled chloride transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The SLC12 family of chloride transporters contribute to ion fluxes across a variety of tissues, particularly in the kidney and choroid plexus of the brain. Within this family, further subfamilies are identifiable: NKCC1, NKCC2 and NCC constitute a group of therapeutically-relevant transporters, targets for loop and thiazide diuretics. These 12 TM proteins exhibit cytoplasmic termini and an extended extracellular loop at TM7/8 and are kidney-specific (NKCC2 and NCC) or show a more widespread distribution (NKCC1). A second family, the K-Cl co-transporters are also 12 TM domain proteins with cytoplasmic termini, but with an extended extracellular loop at TM 5/6. CCC6 exhibits structural similarities with the K-Cl co-transporters, while CCC9 is divergent, with 11 TM domains and a cytoplasmic N-terminus and extracellular C-terminus.

Transporters

972
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NKCC2 (Kidney-specific Na-K-Cl symporter / SLC12A1) C Show summary » More detailed page go icon to follow link

NKCC1 (Basolateral Na-K-Cl symporter / SLC12A2) C Show summary »

NCC (Na-Cl symporter / SLC12A3) C Show summary » More detailed page go icon to follow link

KCC1 (K-Cl cotransporter 1 / SLC12A4) C Show summary »

KCC2 (K-Cl cotransporter 2 / SLC12A5) C Show summary »


Target Id 972
Nomenclature K-Cl cotransporter 2
Systematic nomenclature SLC12A5
Common abbreviation KCC2
Previous and unofficial names Electroneutral potassium-chloride cotransporter 2 | erythroid K-Cl cotransporter 2 | furosemide-sensitive K-Cl cotransporter | neuronal-specific K-Cl cotransporter | solute carrier family 12, (potassium-chloride transporter) member 5 | solute carrier family 12 (potassium/chloride transporter), member 5 | solute carrier family 12 (potassium-chloride transporter), member 5 | solute carrier family 12
Genes SLC12A5 (Hs), Slc12a5 (Mm), Slc12a5 (Rn)
Ensembl ID ENSG00000124140 (Hs), ENSMUSG00000017740 (Mm), ENSRNOG00000018111 (Rn)
UniProtKB AC Q9H2X9 (Hs), Q91V14 (Mm), Q63633 (Rn)
Bioparadigms SLC Tables SLC12A5 (Hs)
RESOLUTE SLC12A5 (Hs)
Inhibitors
VU0240551 pIC50 6.3 [1]
DIOA
Stoichiometry 1 K+ : 1 Cl- (out)

KCC3 (K-Cl cotransporter 3 / SLC12A6) C Show summary »

KCC4 (K-Cl cotransporter 4 / SLC12A7) C Show summary »

CCC9 (Cation-chloride cotransporter 9 / SLC12A8) C Show summary »

CCC6 (Cation-chloride cotransporter 6 / SLC12A9) Show summary »

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Further reading

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References

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How to cite this family page

Database page citation:

SLC12 family of cation-coupled chloride transporters. Accessed on 21/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=184.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.