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SLC19 family of vitamin transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The B vitamins folic acid and thiamine are transported across the cell membrane, particularly in the intestine, kidneys and placenta, using pH differences as driving forces. Topological modelling suggests the transporters have 12 TM domains.

Transporters

1014
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FOLT (Reduced folate transporter 1 / SLC19A1) C Show summary »


Target Id 1014
Nomenclature Reduced folate transporter 1
Systematic nomenclature SLC19A1
Common abbreviation FOLT
Previous and unofficial names IFC1 | intestinal folate carrier | placental folate transporter | folate transporter 1 | methotrexate carrier 1 | methotrexate carrier 2 | methotrexate carrier 5 | methotrexate carrier 6 | MTX1 | solute carrier family 19 (sodium/hydrogen exchanger) member 1 | solute carrier family 19 (folate transporter), member 1 | solute carrier family 19 (folate transporter)
Genes SLC19A1 (Hs), Slc19a1 (Mm), Slc19a1 (Rn)
Ensembl ID ENSG00000173638 (Hs), ENSMUSG00000001436 (Mm), ENSRNOG00000001232 (Rn)
UniProtKB AC P41440 (Hs), P41438 (Mm), Q62866 (Rn)
Bioparadigms SLC Tables SLC19A1 (Hs)
Endogenous substrates
thiamine monophosphate [7]
tetrahydrofolic acid [4]
N5-methylfolate [4]
Organic phosphates; in particular, adenine nucleotides
Other tetrahydrofolate-cofactors
Substrates
folic acid [4]
methotrexate
folinic acid
N5-formyltetrahydrofolate
Inhibitors
compound 9 [PMID: 15615544] pKi 6.6 [6]
methotrexate pKi 5.3 [6]
Labelled ligands
[3H]folic acid [1]
[3H]methotrexate [1]
Stoichiometry Folate (in) : organic phosphate (out), precise stoichiometry unknown

ThTr1 (Thiamine transporter 1 / SLC19A2) C Show summary »

ThTr2 (Thiamine transporter 2 / SLC19A3) C Show summary »

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References

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How to cite this family page

Database page citation:

SLC19 family of vitamin transporters. Accessed on 04/10/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=194.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.