Top ▲

SLC19 family of vitamin transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


Click here for help

« Hide

The B vitamins folic acid and thiamine are transported across the cell membrane, particularly in the intestine, kidneys and placenta, using pH differences as driving forces. Topological modelling suggests the transporters have 12 TM domains.


Click here for help

FOLT (Reduced folate transporter 1 / SLC19A1) C Show summary »

ThTr1 (Thiamine transporter 1 / SLC19A2) C Show summary »

Target Id 1015
Nomenclature Thiamine transporter 1
Systematic nomenclature SLC19A2
Common abbreviation ThTr1
Previous and unofficial names TC1 | Thiamine carrier 1 | TRMA | solute carrier family 19 (thiamine transporter), member 2 | DDA1 | solute carrier family 19 (thiamine transporter)
Genes SLC19A2 (Hs), Slc19a2 (Mm), Slc19a2 (Rn)
Ensembl ID ENSG00000117479 (Hs), ENSMUSG00000040918 (Mm), ENSRNOG00000002839 (Rn)
UniProtKB AC O60779 (Hs)
Bioparadigms SLC Tables SLC19A2 (Hs)
Endogenous substrates
Labelled ligands
[3H]thiamine [3]
Stoichiometry A facilitative carrier not known to be coupled to an inorganic or organic ion gradient

ThTr2 (Thiamine transporter 2 / SLC19A3) C Show summary »


Click here for help

Show »

Further reading

Click here for help

Show »


Click here for help

Show »

How to cite this family page

Database page citation:

SLC19 family of vitamin transporters. Accessed on 24/09/2023. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.