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SLC19 family of vitamin transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The B vitamins folic acid and thiamine are transported across the cell membrane, particularly in the intestine, kidneys and placenta, using pH differences as driving forces. Topological modelling suggests the transporters have 12 TM domains.

Transporters

1016
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FOLT (Reduced folate transporter 1 / SLC19A1) C Show summary »

ThTr1 (Thiamine transporter 1 / SLC19A2) C Show summary »

ThTr2 (Thiamine transporter 2 / SLC19A3) C Show summary »


Target Id 1016
Nomenclature Thiamine transporter 2
Systematic nomenclature SLC19A3
Common abbreviation ThTr2
Previous and unofficial names solute carrier family 19 (sodium/hydrogen exchanger), member 3 | solute carrier family 19 (thiamine transporter), member 3 | solute carrier family 19
Genes SLC19A3 (Hs), Slc19a3 (Mm), Slc19a3 (Rn)
Ensembl ID ENSG00000135917 (Hs), ENSMUSG00000038496 (Mm), ENSRNOG00000015958 (Rn)
UniProtKB AC Q9BZV2 (Hs), Q99PL8 (Mm)
Bioparadigms SLC Tables SLC19A3 (Hs)
Endogenous substrates
thiamine
Labelled ligands
[3H]thiamine [5]
Stoichiometry A facilitative carrier not known to be coupled to an inorganic or organic ion gradient

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How to cite this family page

Database page citation:

SLC19 family of vitamin transporters. Accessed on 24/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=194.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.