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SLC20 family of sodium-dependent phosphate transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The SLC20 family is looked upon not only as ion transporters, but also as retroviral receptors. As ion transporters, they are sometimes referred to as Type III sodium-phosphate co-transporters, alongside Type I (SLC17 family) and Type II (SLC34 family). PiTs are cell-surface transporters, composed of ten TM domains with extracellular C- and N-termini. PiT1 is a focus for dietary phosphate and vitamin D regulation of parathyroid hormone secretion from the parathyroid gland. PiT2 appears to be involved in intestinal absorption of dietary phosphate.


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PiT1 (Sodium-dependent phosphate transporter 1 / SLC20A1) C Show summary »

Target Id 1017
Nomenclature Sodium-dependent phosphate transporter 1
Systematic nomenclature SLC20A1
Common abbreviation PiT1
Previous and unofficial names Gibbon ape leukemia virus receptor 1 | GLVR1 | phosphate transporter 1 | solute carrier family 20 member 1 | solute carrier family 20 (phosphate transporter), member 1 | solute carrier family 20, member 1 | solute carrier family 20
Genes SLC20A1 (Hs), Slc20a1 (Mm), Slc20a1 (Rn)
Ensembl ID ENSG00000144136 (Hs), ENSMUSG00000027397 (Mm), ENSRNOG00000018567 (Rn)
UniProtKB AC Q8WUM9 (Hs), Q61609 (Mm), Q9JJP0 (Rn)
Bioparadigms SLC Tables SLC20A1 (Hs)
AsO43- [1]
phosphate [1]
Stoichiometry >1 Na+ : 1 HPO42- (in)

PiT2 (Sodium-dependent phosphate transporter 2 / SLC20A2) C Show summary »

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How to cite this family page

Database page citation:

SLC20 family of sodium-dependent phosphate transporters. Accessed on 24/09/2023. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.