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SLC24 family of sodium/potassium/calcium exchangers C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The sodium/potassium/calcium exchange family of transporters utilize the extracellular sodium gradient to drive calcium and potassium co-transport out of the cell. As is the case for NCX transporters (SLC8A family), NKCX transporters are thought to be bidirectional, with the possibility of calcium influx following depolarization of the plasma membrane. Topological modeling suggests the presence of 10 TM domains, with a large intracellular loop between the fifth and sixth TM regions.


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NKCX1 (Sodium/potassium/calcium exchanger 1 / SLC24A1) C Show summary »

NKCX2 (Sodium/potassium/calcium exchanger 2 / SLC24A2) Show summary »

Target Id 1046
Nomenclature Sodium/potassium/calcium exchanger 2
Systematic nomenclature SLC24A2
Common abbreviation NKCX2
Previous and unofficial names Retinal cone Na-Ca+K exchanger | NCKX2 | potassium-dependent sodium-calcium exchanger | solute carrier family 24, member 2 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 | solute carrier family 24 (sodium/potassium/calcium exchanger)
Genes SLC24A2 (Hs), Slc24a2 (Mm), Slc24a2 (Rn)
Ensembl ID ENSG00000155886 (Hs), ENSMUSG00000037996 (Mm), ENSRNOG00000008169 (Rn)
UniProtKB AC Q9UI40 (Hs), O54701 (Rn)
Bioparadigms SLC Tables SLC24A2 (Hs)

NKCX3 (Sodium/potassium/calcium exchanger 3 / SLC24A3) Show summary »

NKCX4 (Sodium/potassium/calcium exchanger 4 / SLC24A4) Show summary » More detailed page go icon to follow link

NKCX5 (Sodium/potassium/calcium exchanger 5 / SLC24A5) Show summary »

NKCX6 (Sodium/potassium/calcium exchanger 6 / SLC24A6) C Show summary »


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Further reading

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How to cite this family page

Database page citation:

SLC24 family of sodium/potassium/calcium exchangers. Accessed on 11/12/2023. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.