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Mitochondrial di- and tri-carboxylic acid transporter subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Mitochondrial di- and tri-carboxylic acid transporters are grouped on the basis of commonality of substrates and include the citrate transporter which facilitates citric acid export from the mitochondria to allow the generation of oxalacetic acid and acetyl CoA through the action of ATP:citrate lyase.


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CIC (Mitochondrial citrate transporter / SLC25A1) C Show summary »

Target Id 1051
Nomenclature Mitochondrial citrate transporter
Systematic nomenclature SLC25A1
Common abbreviation CIC
Previous and unofficial names citrate isocitrate carrier | Citrate transport protein | CTP | SLC20A3 | solute carrier family 20 (mitochondrial citrate transporter), member 3 | mitochondrial tricarboxylate carrier | solute carrier family 25 (mitochondrial carrier; citrate transporter) member 1 | Dgsj | solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 | solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1 | solute carrier family 25 (mitochondrial carrier
Genes SLC25A1 (Hs), Slc25a1 (Mm), Slc25a1 (Rn)
Ensembl ID ENSG00000100075 (Hs), ENSMUSG00000003528 (Mm), ENSRNOG00000038001 (Rn)
UniProtKB AC P53007 (Hs), P32089 (Rn)
Bioparadigms SLC Tables SLC25A1 (Hs)
citric acid
malic acid
phosphoenolpyruvic acid
CTPI-2 pKd 5.5 [1]
1,2,3-benzenetricarboxylic acid
Stoichiometry Malate2- (in) : H-citrate2- (out)
Comment A potential clinical target for modulating cytosolic citrate and disordered lipid metabolism related to metabolic diseases [2].

DIC (Mitochondrial dicarboxylate transporter / SLC25A10) C Show summary »

OGC (Mitochondrial oxoglutarate carrier / SLC25A11) C Show summary »

ODC (Mitochondrial oxodicarboxylate carrier / SLC25A21) C Show summary »

SLC25A34 Show summary »

SLC25A35 Show summary »


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How to cite this family page

Database page citation:

Mitochondrial di- and tri-carboxylic acid transporter subfamily. Accessed on 24/09/2023. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.