SLC25 family of mitochondrial transporters | Transporters | IUPHAR/BPS Guide to PHARMACOLOGY

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SLC superfamily of solute carriers
SLC25 family of mitochondrial transporters

SLC25 family of mitochondrial transporters C

Contents

Overview
Subfamilies
Further reading
NC-IUPHAR subcommittee and family contributors
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Overview

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Mitochondrial carriers are nuclear-encoded proteins, which translocate solutes across the inner mitochondrial membrane. Mitochondrial carriers are functional as monomers and have six TM alpha-helices and the termini in the mitochondrial intermembrane space.

Subfamilies

Further reading

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* Key recommended reading is highlighted with an asterisk

* Baffy G. (2017) Mitochondrial uncoupling in cancer cells: Liabilities and opportunities. Biochim Biophys Acta, 1858 (8): 655-664. [PMID:28088333]

Bertholet AM, Kirichok Y. (2017) UCP1: A transporter for H⁺ and fatty acid anions. Biochimie, 134: 28-34. [PMID:27984203]

Cioffi F, Senese R, de Lange P, Goglia F, Lanni A, Lombardi A. (2009) Uncoupling proteins: a complex journey to function discovery. Biofactors, 35 (5): 417-28. [PMID:19626697]

* Crichton PG, Lee Y, Kunji ER. (2017) The molecular features of uncoupling protein 1 support a conventional mitochondrial carrier-like mechanism. Biochimie, 134: 35-50. [PMID:28057583]

* Dolce V, Cappello AR, Capobianco L. (2014) Mitochondrial tricarboxylate and dicarboxylate-tricarboxylate carriers: from animals to plants. IUBMB Life, 66 (7): 462-71. [PMID:25045044]

Halestrap AP. (2009) What is the mitochondrial permeability transition pore?. J Mol Cell Cardiol, 46 (6): 821-31. [PMID:19265700]

Jezek P, Jabůrek M, Garlid KD. (2010) Channel character of uncoupling protein-mediated transport. FEBS Lett, 584 (10): 2135-41. [PMID:20206627]

* Klingenberg M. (2017) UCP1 - A sophisticated energy valve. Biochimie, 134: 19-27. [PMID:27794497]

* Kunji ERS, King MS, Ruprecht JJ, Thangaratnarajah C. (2020) The SLC25 Carrier Family: Important Transport Proteins in Mitochondrial Physiology and Pathology. Physiology (Bethesda), 35 (5): 302-327. [PMID:32783608]

* Lytovchenko O, Kunji ERS. (2017) Expression and putative role of mitochondrial transport proteins in cancer. Biochim Biophys Acta Bioenerg, 1858 (8): 641-654. [PMID:28342810]

* Nicholls DG. (2017) The hunt for the molecular mechanism of brown fat thermogenesis. Biochimie, 134: 9-18. [PMID:27621145]

* Palmieri F, Monné M, Fiermonte G, Palmieri L. (2022) Mitochondrial transport and metabolism of the vitamin B-derived cofactors thiamine pyrophosphate, coenzyme A, FAD and NAD⁺ , and related diseases: A review. IUBMB Life, 74 (7): 592-617. [PMID:35304818]

* Palmieri F, Scarcia P, Monné M. (2020) Diseases Caused by Mutations in Mitochondrial Carrier Genes SLC25: A Review. Biomolecules, 10 (4). DOI: 10.3390/biom10040655 [PMID:32340404]

* Ruprecht JJ, Kunji ERS. (2020) The SLC25 Mitochondrial Carrier Family: Structure and Mechanism. Trends Biochem Sci, 45 (3): 244-258. [PMID:31787485]

Seifert EL, Ligeti E, Mayr JA, Sondheimer N, Hajnóczky G. (2015) The mitochondrial phosphate carrier: Role in oxidative metabolism, calcium handling and mitochondrial disease. Biochem Biophys Res Commun, 464 (2): 369-75. [PMID:26091567]

NC-IUPHAR subcommittee and family contributors

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Transporters. Br J Pharmacol. 182: S404-S496.