Mitochondrial carriers are nuclear-encoded proteins, which translocate solutes across the inner mitochondrial membrane. Mitochondrial carriers are functional as monomers and have six TM alpha-helices and the termini in the mitochondrial intermembrane space.

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* Key recommended reading is highlighted with an asterisk

* Baffy G. (2017) Mitochondrial uncoupling in cancer cells: Liabilities and opportunities. Biochim Biophys Acta, 1858 (8): 655-664. [PMID:28088333]

Bertholet AM, Kirichok Y. (2017) UCP1: A transporter for H⁺ and fatty acid anions. Biochimie, 134: 28-34. [PMID:27984203]

Cioffi F, Senese R, de Lange P, Goglia F, Lanni A, Lombardi A. (2009) Uncoupling proteins: a complex journey to function discovery. Biofactors, 35 (5): 417-28. [PMID:19626697]

* Crichton PG, Lee Y, Kunji ER. (2017) The molecular features of uncoupling protein 1 support a conventional mitochondrial carrier-like mechanism. Biochimie, 134: 35-50. [PMID:28057583]

* Dolce V, Cappello AR, Capobianco L. (2014) Mitochondrial tricarboxylate and dicarboxylate-tricarboxylate carriers: from animals to plants. IUBMB Life, 66 (7): 462-71. [PMID:25045044]

Halestrap AP. (2009) What is the mitochondrial permeability transition pore?. J Mol Cell Cardiol, 46 (6): 821-31. [PMID:19265700]

Jezek P, Jabůrek M, Garlid KD. (2010) Channel character of uncoupling protein-mediated transport. FEBS Lett, 584 (10): 2135-41. [PMID:20206627]

* Klingenberg M. (2017) UCP1 - A sophisticated energy valve. Biochimie, 134: 19-27. [PMID:27794497]

* Kunji ERS, King MS, Ruprecht JJ, Thangaratnarajah C. (2020) The SLC25 Carrier Family: Important Transport Proteins in Mitochondrial Physiology and Pathology. Physiology (Bethesda), 35 (5): 302-327. [PMID:32783608]

* Lytovchenko O, Kunji ERS. (2017) Expression and putative role of mitochondrial transport proteins in cancer. Biochim Biophys Acta Bioenerg, 1858 (8): 641-654. [PMID:28342810]

* Nicholls DG. (2017) The hunt for the molecular mechanism of brown fat thermogenesis. Biochimie, 134: 9-18. [PMID:27621145]

* Palmieri F, Monné M, Fiermonte G, Palmieri L. (2022) Mitochondrial transport and metabolism of the vitamin B-derived cofactors thiamine pyrophosphate, coenzyme A, FAD and NAD⁺ , and related diseases: A review. IUBMB Life, 74 (7): 592-617. [PMID:35304818]

* Palmieri F, Scarcia P, Monné M. (2020) Diseases Caused by Mutations in Mitochondrial Carrier Genes SLC25: A Review. Biomolecules, 10 (4). DOI: 10.3390/biom10040655 [PMID:32340404]

* Ruprecht JJ, Kunji ERS. (2020) The SLC25 Mitochondrial Carrier Family: Structure and Mechanism. Trends Biochem Sci, 45 (3): 244-258. [PMID:31787485]

Seifert EL, Ligeti E, Mayr JA, Sondheimer N, Hajnóczky G. (2015) The mitochondrial phosphate carrier: Role in oxidative metabolism, calcium handling and mitochondrial disease. Biochem Biophys Res Commun, 464 (2): 369-75. [PMID:26091567]

Edmund R.S. Kunji Medical Research Council Mitochondrial Biology Unit University of Cambridge The Keith Peters Building Cambridge Biomedical Campus Hills Road Cambridge CB2 0XY UK