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Mitochondrial amino acid transporter subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Mitochondrial amino acid transporters can be subdivided on the basis of their substrates. Mitochondrial ornithine transporters play a role in the urea cycle by exchanging cytosolic ornithine (L-ornithine and D-ornithine) for mitochondrial citrulline (L-citrulline and D-citrulline) in equimolar amounts. Further members of the family include transporters of S-adenosylmethionine and carnitine.

Transporters

1055
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solute carrier family 25 member 47 / SLC25A47 Show summary »

solute carrier family 25 member 48 / SLC25A48 Show summary »

AGC1 / SLC25A12 C Show summary »

AGC2 / SLC25A13 C Show summary »


Target Id 1055
Nomenclature AGC2
Systematic nomenclature SLC25A13
Previous and unofficial names CTLN2 | mitochondrial aspartate glutamate carrier 2 | calcium-binding mitochondrial carrier protein Aralar2 | solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13 | Ctrn | CITRIN | solute carrier family 25 (aspartate/glutamate carrier), member 13 | solute carrier family 25 (mitochondrial carrier
Genes SLC25A13 (Hs), Slc25a13 (Mm), Slc25a13 (Rn)
Ensembl ID ENSG00000004864 (Hs), ENSMUSG00000015112 (Mm), ENSRNOG00000009957 (Rn)
UniProtKB AC Q9UJS0 (Hs), Q9QXX4 (Mm)
Bioparadigms SLC Tables SLC25A13 (Hs)
RESOLUTE SLC25A13 (Hs)
Substrates
L-glutamic acid
L-aspartic acid
2-amino-3-sulfinopropanoic acid
Stoichiometry Aspartate : glutamate H+ (bidirectional)

GC2 (Mitochondrial glutamate carrier 2 / SLC25A18) C Show summary »

GC1 (Mitochondrial glutamate carrier 1 / SLC25A22) C Show summary »

ORC2 (Mitochondrial ornithine transporter 2 / SLC25A2) C Show summary »

ORC1 (Mitochondrial ornithine transporter 1  / SLC25A15) C Show summary »

CAC (Carnitine/acylcarnitine carrier / SLC25A20) C Show summary »

ORNT3 / SLC25A29 Show summary »

SLC25A38 Show summary »

CGI-69 / SLC25A39 Show summary »

MCFP / SLC25A40 Show summary »

SLC25A44 Show summary »

SLC25A45 Show summary »

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Further reading

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References

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How to cite this family page

Database page citation:

Mitochondrial amino acid transporter subfamily. Accessed on 26/02/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=204.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.