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Mitochondrial amino acid transporter subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Mitochondrial amino acid transporters can be subdivided on the basis of their substrates. Mitochondrial ornithine transporters play a role in the urea cycle by exchanging cytosolic ornithine (L-ornithine and D-ornithine) for mitochondrial citrulline (L-citrulline and D-citrulline) in equimolar amounts. Further members of the family include transporters of S-adenosylmethionine and carnitine.


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solute carrier family 25 member 47 / SLC25A47 Show summary »

solute carrier family 25 member 48 / SLC25A48 Show summary »

AGC1 / SLC25A12 C Show summary »

AGC2 / SLC25A13 C Show summary »

GC2 (Mitochondrial glutamate carrier 2 / SLC25A18) C Show summary »

GC1 (Mitochondrial glutamate carrier 1 / SLC25A22) C Show summary »

ORC2 (Mitochondrial ornithine transporter 2 / SLC25A2) C Show summary »

ORC1 (Mitochondrial ornithine transporter 1  / SLC25A15) C Show summary »

Target Id 1060
Nomenclature Mitochondrial ornithine transporter 1
Systematic nomenclature SLC25A15
Common abbreviation ORC1
Previous and unofficial names ORNT1 | solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 | solute carrier family 25 (mitochondrial carrier ornithine transporter), member 15 | solute carrier family 25 (mitochondrial carrier ornithine transporter)
Genes SLC25A15 (Hs), Slc25a15 (Mm), Slc25a15 (Rn)
Ensembl ID ENSG00000102743 (Hs), ENSMUSG00000031482 (Mm), ENSRNOG00000011881 (Rn)
UniProtKB AC Q9Y619 (Hs), Q9WVD5 (Mm)
Bioparadigms SLC Tables SLC25A15 (Hs)
L-arginine [1]
L-citrulline [1]
L-lysine [1]
L-ornithine [1]
Stoichiometry 1 Ornithine (in) :1 citrulline : 1 H+ (out)

CAC (Carnitine/acylcarnitine carrier / SLC25A20) C Show summary »

ORNT3 / SLC25A29 Show summary »

SLC25A38 Show summary »

CGI-69 / SLC25A39 Show summary »

MCFP / SLC25A40 Show summary »

SLC25A44 Show summary »

SLC25A45 Show summary »


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Further reading

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How to cite this family page

Database page citation:

Mitochondrial amino acid transporter subfamily. Accessed on 11/12/2023. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.