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Mitochondrial amino acid transporter subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Mitochondrial amino acid transporters can be subdivided on the basis of their substrates. Mitochondrial ornithine transporters play a role in the urea cycle by exchanging cytosolic ornithine (L-ornithine and D-ornithine) for mitochondrial citrulline (L-citrulline and D-citrulline) in equimolar amounts. Further members of the family include transporters of S-adenosylmethionine and carnitine.

Transporters

1076
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solute carrier family 25 member 47 / SLC25A47 Show summary »

solute carrier family 25 member 48 / SLC25A48 Show summary »

AGC1 / SLC25A12 C Show summary »

AGC2 / SLC25A13 C Show summary »

GC2 (Mitochondrial glutamate carrier 2 / SLC25A18) C Show summary »

GC1 (Mitochondrial glutamate carrier 1 / SLC25A22) C Show summary »

ORC2 (Mitochondrial ornithine transporter 2 / SLC25A2) C Show summary »

ORC1 (Mitochondrial ornithine transporter 1  / SLC25A15) C Show summary »

CAC (Carnitine/acylcarnitine carrier / SLC25A20) C Show summary »


Target Id 1076
Nomenclature Carnitine/acylcarnitine carrier
Systematic nomenclature SLC25A20
Common abbreviation CAC
Previous and unofficial names CACT | carnitine/acylcarnitine translocase | carnitine-acylcarnitine carrier | mitochondrial carnitine/acylcarnitine carrier protein | solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 | solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 | solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase)
Genes SLC25A20 (Hs), Slc25a20 (Mm), Slc25a20 (Rn)
Ensembl ID ENSG00000178537 (Hs), ENSMUSG00000032602 (Mm), ENSRNOG00000020288 (Rn)
UniProtKB AC O43772 (Hs), Q9Z2Z6 (Mm), P97521 (Rn)
Bioparadigms SLC Tables SLC25A20 (Hs)
Comment Exchanges cytosolic acylcarnitine for mitochondrial carnitine

ORNT3 / SLC25A29 Show summary »

SLC25A38 Show summary »

CGI-69 / SLC25A39 Show summary »

MCFP / SLC25A40 Show summary »

SLC25A44 Show summary »

SLC25A45 Show summary »

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References

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How to cite this family page

Database page citation:

Mitochondrial amino acid transporter subfamily. Accessed on 23/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=204.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.