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Mitochondrial nucleotide transporter subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Mitochondrial nucleotide transporters, defined by structural similarlities, include the adenine nucleotide translocator family (SLC25A4, SLC25A5, SLC25A6 and SLC25A31), which under conditions of aerobic metabolism, allow coupling between mitochondrial oxidative phosphorylation and cytosolic energy consumption by exchanging cytosolic ADP for mitochondrial ATP. Further members of the mitochondrial nucleotide transporter subfamily convey diverse substrates including CoA, although not all members have had substrates identified.

Transporters

1071
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ANT1 (Mitochondrial adenine nucleotide translocator 1 / SLC25A4) C Show summary »

ANT2 (Mitochondrial adenine nucleotide translocator 2 / SLC25A5) C Show summary »

ANT3 (Mitochondrial adenine nucleotide translocator 3 / SLC25A6) C Show summary »

ANT4 (Mitochondrial adenine nucleotide translocator 4 / SLC25A31) C Show summary »

GDC (Graves disease carrier / SLC25A16) C Show summary »


Target Id 1071
Nomenclature Graves disease carrier
Systematic nomenclature SLC25A16
Common abbreviation GDC
Previous and unofficial names Graves disease autoantigen | GDC | solute carrier family 25 member 16 | GDA | ML7 | solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16 | solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16 | solute carrier family 25 (mitochondrial carrier), member 16 | solute carrier family 25 (mitochondrial carrier) | solute carrier family 25 (mitochondrial carrier
Genes SLC25A16 (Hs), Slc25a16 (Mm), Slc25a16 (Rn)
Ensembl ID ENSG00000122912 (Hs), ENSMUSG00000071253 (Mm), ENSRNOG00000000387 (Rn)
UniProtKB AC P16260 (Hs), Q8C0K5 (Mm), P16261 (Rn)
Bioparadigms SLC Tables SLC25A16 (Hs)
RESOLUTE SLC25A16 (Hs)
Substrates
CoA and congeners
Stoichiometry CoA (in)

PMP34 (Peroxisomal membrane protein / SLC25A17) C Show summary »

DNC (Deoxynucleotide carrier 1 / SLC25A19) C Show summary »

SAMC1 (S-Adenosylmethionine carrier / SLC25A26) C Show summary »

SLC25A42 Show summary »

APC1 (Mitochondrial phosphate carrier 1 / SLC25A24) C Show summary »

APC2 (Mitochondrial phosphate carrier 2 / SLC25A23) C Show summary »

APC3 (Mitochondrial phosphate carrier 3 / SLC25A25) C Show summary »

MFTC (MFT / SLC25A32) Show summary »

PNC1 / SLC25A33 Show summary »

PNC2 (SLC25A36) Show summary »

SCaMC-3L / SLC25A41 Show summary »

SLC25A43 Show summary »

Further reading

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How to cite this family page

Database page citation:

Mitochondrial nucleotide transporter subfamily. Accessed on 14/06/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=206.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.