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Mitochondrial nucleotide transporter subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Mitochondrial nucleotide transporters, defined by structural similarlities, include the adenine nucleotide translocator family (SLC25A4, SLC25A5, SLC25A6 and SLC25A31), which under conditions of aerobic metabolism, allow coupling between mitochondrial oxidative phosphorylation and cytosolic energy consumption by exchanging cytosolic ADP for mitochondrial ATP. Further members of the mitochondrial nucleotide transporter subfamily convey diverse substrates including CoA, although not all members have had substrates identified.

Transporters

1073
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ANT1 (Mitochondrial adenine nucleotide translocator 1 / SLC25A4) C Show summary »

ANT2 (Mitochondrial adenine nucleotide translocator 2 / SLC25A5) C Show summary »

ANT3 (Mitochondrial adenine nucleotide translocator 3 / SLC25A6) C Show summary »

ANT4 (Mitochondrial adenine nucleotide translocator 4 / SLC25A31) C Show summary »

GDC (Graves disease carrier / SLC25A16) C Show summary »

PMP34 (Peroxisomal membrane protein / SLC25A17) C Show summary »

DNC (Deoxynucleotide carrier 1 / SLC25A19) C Show summary »


Target Id 1073
Nomenclature Deoxynucleotide carrier 1
Systematic nomenclature SLC25A19
Common abbreviation DNC
Previous and unofficial names Mitochondrial thiamine pyrophosphate carrier | MCPHA | MUP1 | TPC | DNC1 | solute carrier family 25 (mitochondrial deoxynucleotide carrier), member 19 | solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 | solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier)
Genes SLC25A19 (Hs), Slc25a19 (Mm), Slc25a19 (Rn)
Ensembl ID ENSG00000125454 (Hs), ENSMUSG00000020744 (Mm), ENSRNOG00000003918 (Rn)
UniProtKB AC Q9HC21 (Hs), Q9DAM5 (Mm)
Bioparadigms SLC Tables SLC25A19 (Hs)
RESOLUTE SLC25A19 (Hs)
Substrates
Deoxynucleotide Diphosphates (dNDPs)
Deoxynucleotide Triphosphates (dNTPs)
Dideoxynucleotide Triphosphates (ddNTPs)
Nucleotide Diphosphates (NDPs)
Stoichiometry dNDP (in) : ATP (out)

SAMC1 (S-Adenosylmethionine carrier / SLC25A26) C Show summary »

SLC25A42 Show summary »

APC1 (Mitochondrial phosphate carrier 1 / SLC25A24) C Show summary »

APC2 (Mitochondrial phosphate carrier 2 / SLC25A23) C Show summary »

APC3 (Mitochondrial phosphate carrier 3 / SLC25A25) C Show summary »

MFTC (MFT / SLC25A32) Show summary »

PNC1 / SLC25A33 Show summary »

PNC2 (SLC25A36) Show summary »

SCaMC-3L / SLC25A41 Show summary »

SLC25A43 Show summary »

Further reading

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How to cite this family page

Database page citation:

Mitochondrial nucleotide transporter subfamily. Accessed on 27/02/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=206.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.