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Mitochondrial nucleotide transporter subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Mitochondrial nucleotide transporters, defined by structural similarlities, include the adenine nucleotide translocator family (SLC25A4, SLC25A5, SLC25A6 and SLC25A31), which under conditions of aerobic metabolism, allow coupling between mitochondrial oxidative phosphorylation and cytosolic energy consumption by exchanging cytosolic ADP for mitochondrial ATP. Further members of the mitochondrial nucleotide transporter subfamily convey diverse substrates including CoA, although not all members have had substrates identified.

Transporters

1079
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ANT1 (Mitochondrial adenine nucleotide translocator 1 / SLC25A4) C Show summary »

ANT2 (Mitochondrial adenine nucleotide translocator 2 / SLC25A5) C Show summary »

ANT3 (Mitochondrial adenine nucleotide translocator 3 / SLC25A6) C Show summary »

ANT4 (Mitochondrial adenine nucleotide translocator 4 / SLC25A31) C Show summary »

GDC (Graves disease carrier / SLC25A16) C Show summary »

PMP34 (Peroxisomal membrane protein / SLC25A17) C Show summary »

DNC (Deoxynucleotide carrier 1 / SLC25A19) C Show summary »

SAMC1 (S-Adenosylmethionine carrier / SLC25A26) C Show summary »

SLC25A42 Show summary »

APC1 (Mitochondrial phosphate carrier 1 / SLC25A24) C Show summary »

APC2 (Mitochondrial phosphate carrier 2 / SLC25A23) C Show summary »

APC3 (Mitochondrial phosphate carrier 3 / SLC25A25) C Show summary »


Target Id 1079
Nomenclature Mitochondrial phosphate carrier 3
Systematic nomenclature SLC25A25
Common abbreviation APC3
Previous and unofficial names MCSC | PCSCL | ATP-Mg/Pi carrier | calcium-binding mitochondrial carrier protein SCaMC-2 | mitochondrial ATP-Mg/Pi carrier protein | mitochondrial Ca2+-dependent solute carrier | small calcium-binding mitochondrial carrier protein 2 | solute carrier family 25 member 25 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 | solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 | solute carrier family 25 (mitochondrial carrier
Genes SLC25A25 (Hs), Slc25a25 (Mm), Slc25a25 (Rn)
Ensembl ID ENSG00000148339 (Hs), ENSMUSG00000026819 (Mm), ENSRNOG00000014338 (Rn)
UniProtKB AC Q6KCM7 (Hs), A2ASZ8 (Mm), Q8K3P6 (Rn)
Bioparadigms SLC Tables SLC25A25 (Hs)

MFTC (MFT / SLC25A32) Show summary »

PNC1 / SLC25A33 Show summary »

PNC2 (SLC25A36) Show summary »

SCaMC-3L / SLC25A41 Show summary »

SLC25A43 Show summary »

How to cite this family page

Database page citation:

Mitochondrial nucleotide transporter subfamily. Accessed on 24/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=206.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.