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Mitochondrial uncoupling proteins C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Mitochondrial uncoupling proteins allow dissipation of the mitochondrial proton gradient associated with thermogenesis and regulation of radical formation.


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UCP1 (Uncoupling protein 1 / SLC25A7) C Show summary »

Target Id 1066
Nomenclature Uncoupling protein 1
Systematic nomenclature SLC25A7
Common abbreviation UCP1
Previous and unofficial names Thermogenin | solute carrier family 25 member 7 | mitochondrial brown fat uncoupling protein 1 | uncoupling protein 1 mitochondrial | uncoupling protein 1 (mitochondrial, proton carrier) | uncoupling protein 1 (mitochondrial
Genes UCP1 (Hs), Ucp1 (Mm), Ucp1 (Rn)
Ensembl ID ENSG00000109424 (Hs), ENSMUSG00000031710 (Mm), ENSRNOG00000003580 (Rn)
UniProtKB AC P25874 (Hs), P12242 (Mm), P04633 (Rn)
Bioparadigms SLC Tables SLC25A7 (Hs)
Stoichiometry H+ (in)

UCP2 (Uncoupling protein 2 / SLC25A8) C Show summary »

UCP3 (Uncoupling protein 3 / SLC25A9) C Show summary »

UCP4 (Uncoupling protein 4 / SLC25A27) C Show summary »

UCP5 (Uncoupling protein 5 / SLC25A14) C Show summary »

KMCP1 / SLC25A30 C Show summary »

How to cite this family page

Database page citation:

Mitochondrial uncoupling proteins. Accessed on 18/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.