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Mitochondrial uncoupling proteins C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Mitochondrial uncoupling proteins allow dissipation of the mitochondrial proton gradient associated with thermogenesis and regulation of radical formation.


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UCP1 (Uncoupling protein 1 / SLC25A7) C Show summary »

UCP2 (Uncoupling protein 2 / SLC25A8) C Show summary »

Target Id 1067
Nomenclature Uncoupling protein 2
Systematic nomenclature SLC25A8
Common abbreviation UCP2
Previous and unofficial names mitochondrial uncoupling protein 2 | solute carrier family 25 member 8 | Uncoupling protein 2 mitochondrial | uncoupling protein 2 (mitochondrial, proton carrier) | uncoupling protein 2 (mitochondrial
Genes UCP2 (Hs), Ucp2 (Mm), Ucp2 (Rn)
Ensembl ID ENSG00000175567 (Hs), ENSMUSG00000033685 (Mm), ENSRNOG00000017854 (Rn)
UniProtKB AC P55851 (Hs), P70406 (Mm), P56500 (Rn)
Bioparadigms SLC Tables SLC25A8 (Hs)
Stoichiometry H+ (in)

UCP3 (Uncoupling protein 3 / SLC25A9) C Show summary »

UCP4 (Uncoupling protein 4 / SLC25A27) C Show summary »

UCP5 (Uncoupling protein 5 / SLC25A14) C Show summary »

KMCP1 / SLC25A30 C Show summary »

How to cite this family page

Database page citation:

Mitochondrial uncoupling proteins. Accessed on 10/12/2023. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.