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Mitochondrial uncoupling proteins C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Mitochondrial uncoupling proteins allow dissipation of the mitochondrial proton gradient associated with thermogenesis and regulation of radical formation.


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UCP1 (Uncoupling protein 1 / SLC25A7) C Show summary »

UCP2 (Uncoupling protein 2 / SLC25A8) C Show summary »

UCP3 (Uncoupling protein 3 / SLC25A9) C Show summary »

UCP4 (Uncoupling protein 4 / SLC25A27) C Show summary »

UCP5 (Uncoupling protein 5 / SLC25A14) C Show summary »

Target Id 1070
Nomenclature Uncoupling protein 5
Systematic nomenclature SLC25A14
Common abbreviation UCP5
Previous and unofficial names BMCP1 | UCP5 | brain mitochondrial carrier protein 1 | solute carrier family 25 (mitochondrial carrier, brain), member 14 | UCP5L | UCP5S | solute carrier family 25 (mitochondrial carrier
Genes SLC25A14 (Hs), Slc25a14 (Mm), Slc25a14 (Rn)
Ensembl ID ENSG00000102078 (Hs), ENSMUSG00000031105 (Mm), ENSRNOG00000006871 (Rn)
UniProtKB AC O95258 (Hs), Q9Z2B2 (Mm)
Bioparadigms SLC Tables SLC25A14 (Hs)
Stoichiometry H+ (in)

KMCP1 / SLC25A30 C Show summary »

How to cite this family page

Database page citation:

Mitochondrial uncoupling proteins. Accessed on 24/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.