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SLC27 family of fatty acid transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Fatty acid transporter proteins (FATPs) are a family (SLC27) of six transporters (FATP1-6). They have at least one, and possibly six [5,11], transmembrane segments, and are predicted on the basis of structural similarities to form dimers. SLC27 members have several structural domains: integral membrane associated domain, peripheral membrane associated domain, FATP signature, intracellular AMP binding motif, dimerization domain, lipocalin motif, and an ER localization domain (identified in FATP4 only) [3,8-9]. These transporters are unusual in that they appear to express intrinsic very long-chain acyl-CoA synthetase (EC 6.2.1.- , EC 6.2.1.7) enzyme activity. Within the cell, these transporters may associate with plasma and peroxisomal membranes. FATP1-4 and -6 transport long- and very long-chain fatty acids, while FATP5 transports long-chain fatty acids as well as bile acids [1,7,11].

Transporters

1111
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FATP1 (Fatty acid transport protein 1 / SLC27A1) C Show summary » More detailed page go icon to follow link

FATP2 (Fatty acid transport protein 2 / SLC27A2) C Show summary »

FATP3 (Fatty acid transport protein 3 / SLC27A3) C Show summary »

FATP4 (Fatty acid transport protein 4 / SLC27A4) C Show summary »


Target Id 1111
Nomenclature Fatty acid transport protein 4
Systematic nomenclature SLC27A4
Common abbreviation FATP4
Previous and unofficial names ACSVL4 | long-chain fatty acid transport protein 4 | solute carrier family 27 (fatty acid transporter), member 4 | solute carrier family 27 (fatty acid transporter)
Genes SLC27A4 (Hs), Slc27a4 (Mm), Slc27a4 (Rn)
Ensembl ID ENSG00000167114 (Hs), ENSMUSG00000059316 (Mm), ENSRNOG00000014369 (Rn)
UniProtKB AC Q6P1M0 (Hs), Q91VE0 (Mm)
Bioparadigms SLC Tables SLC27A4 (Hs)
Endogenous substrates palmitic acid > oleic acid > butyric acid, γ-linolenic acid > arachidonic acid  [12]
Endogenous substrates palmitic acid , oleic acid > γ-linolenic acid > octanoic acid  [4]
Inhibitors
compound 1l [PMID: 16644217] pIC50 7.1 [2]
Comment FATP4 is genetically linked to restrictive dermopathy.

FATP5 (Fatty acid transport protein 5 / SLC27A5) C Show summary »

FATP6 (Fatty acid transport protein 6 / SLC27A6) C Show summary »

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Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.