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Fatty acid transport protein 1

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Target not currently curated in GtoImmuPdb

Target id: 1108

Nomenclature: Fatty acid transport protein 1

Abbreviated Name: FATP1

Systematic Nomenclature: SLC27A1

Family: SLC27 family of fatty acid transporters

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 646 19p13.11 SLC27A1 solute carrier family 27 member 1
Mouse 1 646 8 B3.3 Slc27a1 solute carrier family 27 (fatty acid transporter), member 1
Rat 1 646 16p14 Slc27a1 solute carrier family 27 member 1
Previous and Unofficial Names Click here for help
Long-chain fatty acid transport protein 1 | solute carrier family 27 member 1 | ACSVL5 | FATP | solute carrier family 27 (fatty acid transporter), member 1 | solute carrier family 27 (fatty acid transporter)
Database Links Click here for help
Specialist databases
Bioparadigms SLC Tables SLC27A1 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
Endogenous substrates (Human)
arachidonic acid > palmitic acid > oleic acid > butyric acid  [3]
Endogenous substrates (Human)
palmitic acid > oleic acid > γ-linolenic acid > octanoic acid  [1]

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 5k [PMID: 23528296] Small molecule or natural product Hs Inhibition 7.3 pIC50 2
pIC50 7.3 (IC50 4.6x10-8 M) [2]
Immuno Process Associations
Immuno Process:  Cytokine production & signalling


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1. Gimeno RE, Ortegon AM, Patel S, Punreddy S, Ge P, Sun Y, Lodish HF, Stahl A. (2003) Characterization of a heart-specific fatty acid transport protein. J Biol Chem, 278 (18): 16039-44. [PMID:12556534]

2. Matsufuji T, Ikeda M, Naito A, Hirouchi M, Kanda S, Izumi M, Harada J, Shinozuka T. (2013) Arylpiperazines as fatty acid transport protein 1 (FATP1) inhibitors with improved potency and pharmacokinetic properties. Bioorg Med Chem Lett, 23 (9): 2560-5. [PMID:23528296]

3. Schaffer JE, Lodish HF. (1994) Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein. Cell, 79 (3): 427-36. [PMID:7954810]


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