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SLC27 family of fatty acid transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Fatty acid transporter proteins (FATPs) are a family (SLC27) of six transporters (FATP1-6). They have at least one, and possibly six [5,11], transmembrane segments, and are predicted on the basis of structural similarities to form dimers. SLC27 members have several structural domains: integral membrane associated domain, peripheral membrane associated domain, FATP signature, intracellular AMP binding motif, dimerization domain, lipocalin motif, and an ER localization domain (identified in FATP4 only) [3,8-9]. These transporters are unusual in that they appear to express intrinsic very long-chain acyl-CoA synthetase (EC 6.2.1.- , EC enzyme activity. Within the cell, these transporters may associate with plasma and peroxisomal membranes. FATP1-4 and -6 transport long- and very long-chain fatty acids, while FATP5 transports long-chain fatty acids as well as bile acids [1,7,11].


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FATP1 (Fatty acid transport protein 1 / SLC27A1) C Show summary » More detailed page go icon to follow link

FATP2 (Fatty acid transport protein 2 / SLC27A2) C Show summary »

FATP3 (Fatty acid transport protein 3 / SLC27A3) C Show summary »

FATP4 (Fatty acid transport protein 4 / SLC27A4) C Show summary »

FATP5 (Fatty acid transport protein 5 / SLC27A5) C Show summary »

Target Id 1112
Nomenclature Fatty acid transport protein 5
Systematic nomenclature SLC27A5
Common abbreviation FATP5
Previous and unofficial names BACS | BAL | bile acid CoA ligase | Bile acyl-CoA synthetase | cholate-CoA ligase | very long-chain acyl-CoA synthetase homolog 2 | VLCSH2 | fatty-acid-Coenzyme A ligase, very long-chain 3 | BA-CoA ligase | solute carrier family 27 (fatty acid transporter), member 5 | very long-chain acyl-CoA synthetase-related protein | ACSB | ACSVL6 | FACVL3 | solute carrier family 27 (fatty acid transporter)
Genes SLC27A5 (Hs), Slc27a5 (Mm), Slc27a5 (Rn)
Ensembl ID ENSG00000083807 (Hs), ENSMUSG00000030382 (Mm), ENSRNOG00000019626 (Rn)
UniProtKB AC Q9Y2P5 (Hs), Q4LDG0 (Mm), Q9ES38 (Rn)
Bioparadigms SLC Tables SLC27A5 (Hs)

FATP6 (Fatty acid transport protein 6 / SLC27A6) C Show summary »


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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.