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SLC31 family of copper transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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SLC31 family members, alongside the Cu-ATPases are involved in the regulation of cellular copper levels. The CTR1 transporter is a cell-surface transporter to allow monovalent copper accumulation into cells, while CTR2 appears to be a vacuolar/vesicular transporter [4]. Functional copper transporters appear to be trimeric with each subunit having three TM regions and an extracellular N-terminus. CTR1 is considered to be a higher affinity copper transporter compared to CTR2. The stoichiometry of copper accumulation is unclear, but appears to be energy-independent [3].

Transporters

1132
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CTR1 (Copper transporter 1 / SLC31A1) C Show summary »

CTR2 (Copper transporter 2 / SLC31A2) C Show summary »


Target Id 1132
Nomenclature Copper transporter 2
Systematic nomenclature SLC31A2
Common abbreviation CTR2
Previous and unofficial names COPT2 | solute carrier family 31 (copper transporters), member 2 | solute carrier family 31 (copper transporter), member 2 | solute carrier family 31
Genes SLC31A2 (Hs), Slc31a2 (Mm), Slc31a2 (Rn)
Ensembl ID ENSG00000136867 (Hs), ENSMUSG00000066152 (Mm), ENSRNOG00000013631 (Rn)
UniProtKB AC O15432 (Hs), Q9CPU9 (Mm)
Bioparadigms SLC Tables SLC31A2 (Hs)
Endogenous substrates
copper
Substrates
cisplatin [1]
Stoichiometry Unknown

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How to cite this family page

Database page citation:

SLC31 family of copper transporters. Accessed on 17/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=218.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.