Top ▲

SLC34 family of sodium phosphate co-transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide

The SLC34 family are sometimes referred to as Type II sodium-phosphate co-transporters, alongside Type I (SLC17 family) and Type III (SLC20 family) transporters. Topological modelling suggests eight TM domains with C- and N- termini in the cytoplasm, and a re-entrant loop at TM7/8. SLC34 family members are expressed on the apical surfaces of epithelia in the intestine and kidneys to regulate body phosphate levels, principally NaPi-IIa and NaPi-IIb, respectively. NaPi-IIa and NaPi-IIb are electrogenic, while NaPiIIc is electroneutral [1].

Transporters

1135
Click here for help

NaPi-IIa (Sodium phosphate 1 / SLC34A1) C Show summary »


Target Id 1135
Nomenclature Sodium phosphate 1
Systematic nomenclature SLC34A1
Common abbreviation NaPi-IIa
Previous and unofficial names NAPI-3 | NPT2 | NPTIIa | SLC11 | SLC17A2 | Na+-phosphate cotransporter type II | solute carrier family 17 (sodium phosphate), member 2 | Na(+)-dependent phosphate cotransporter 2A | NAPI2A | sodium/phosphate cotransporter 2A | sodium-dependent phosphate transport protein 2A | sodium-phosphate transport protein 2A | solute carrier family 17 (sodium/hydrogen exchanger) member 2 | solute carrier family 34 (sodium phosphate) member 1 | Na/Pi cotransporter | renal Na+/Pi transporter | solute carrier family 34 (type II sodium/phosphate contransporter), member 1 | solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 | solute carrier family 34 (sodium phosphate)
Genes SLC34A1 (Hs), Slc34a1 (Mm), Slc34a1 (Rn)
Ensembl ID ENSG00000131183 (Hs), ENSMUSG00000021490 (Mm), ENSRNOG00000015262 (Rn)
UniProtKB AC Q06495 (Hs), Q60825 (Mm), Q06496 (Rn)
Bioparadigms SLC Tables SLC34A1 (Hs)
Stoichiometry 3 Na+ : 1 HPO42- (in) [4]

NaPi-IIb (Sodium phosphate 2 / SLC34A2) C Show summary »

NaPi-IIc (Sodium phosphate 3 / SLC34A3) C Show summary »

Comments

Click here for help

Show »

Further reading

Click here for help

Show »

References

Click here for help

Show »

How to cite this family page

Database page citation:

SLC34 family of sodium phosphate co-transporters. Accessed on 26/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=221.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.