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SLC34 family of sodium phosphate co-transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The SLC34 family are sometimes referred to as Type II sodium-phosphate co-transporters, alongside Type I (SLC17 family) and Type III (SLC20 family) transporters. Topological modelling suggests eight TM domains with C- and N- termini in the cytoplasm, and a re-entrant loop at TM7/8. SLC34 family members are expressed on the apical surfaces of epithelia in the intestine and kidneys to regulate body phosphate levels, principally NaPi-IIa and NaPi-IIb, respectively. NaPi-IIa and NaPi-IIb are electrogenic, while NaPiIIc is electroneutral [1].


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NaPi-IIa (Sodium phosphate 1 / SLC34A1) C Show summary »

NaPi-IIb (Sodium phosphate 2 / SLC34A2) C Show summary »

NaPi-IIc (Sodium phosphate 3 / SLC34A3) C Show summary »

Target Id 1137
Nomenclature Sodium phosphate 3
Systematic nomenclature SLC34A3
Common abbreviation NaPi-IIc
Previous and unofficial names Na(+)/Pi cotransporter 2C | Na(+)-dependent phosphate cotransporter 2C | Na+/Pi-cotransporter type IIc | naPi-2c | sodium/phosphate cotransporter 2C | sodium-dependent phosphate transport protein 2C | sodium-phosphate transport protein 2C | solute carrier family 34 (sodium phosphate), member 3 | solute carrier family 34 (type II sodium/phosphate contransporter), member 3 | solute carrier family 34 (type II sodium/phosphate cotransporter), member 3 | solute carrier family 34 (sodium phosphate)
Genes SLC34A3 (Hs), Slc34a3 (Mm), Slc34a3 (Rn)
Ensembl ID ENSG00000198569 (Hs), ENSMUSG00000006469 (Mm), ENSRNOG00000010451 (Rn)
UniProtKB AC Q8N130 (Hs), Q80SU6 (Mm), Q8K4R8 (Rn)
Bioparadigms SLC Tables SLC34A3 (Hs)
Stoichiometry 2 Na+ : 1 HPO42- (in) [1]


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Further reading

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How to cite this family page

Database page citation:

SLC34 family of sodium phosphate co-transporters. Accessed on 17/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.