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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Glycoprotein formation in the Golgi and endoplasmic reticulum relies on the accumulation of nucleotide-conjugated sugars via the SLC35 family of transporters. These transporters have a predicted topology of 10 TM domains, with cytoplasmic termini, and function as exchangers, swopping nucleoside monophosphates for the corresponding nucleoside diphosphate conjugated sugar. Five subfamilies of transporters have been identified on the basis of sequence similarity, namely SLC35A1, SLC35A2, SLC35A3, SLC35A4 and SLC35A5; SLC35B1, SLC35B2, SLC35B3 and SLC35B4; SLC35C1 and SLC35C2; SLC35D1, SL35D1, SLC35D2 and SLC35D3, and the subfamily of orphan SLC35 transporters, SLC35E1-4 and SLC35F1-5.
CMP-sialic acid transporter / SLC35A1 C Show summary » |
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UDP-galactose transporter / SLC35A2 C Show summary » |
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UDP-N-acetylglucosamine transporter / SLC35A3 C Show summary » |
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MGC2541 / SLC35A4 Show summary » |
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FLJ11130 / SLC35A5 Show summary » |
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UGTREL1 / SLC35B1 Show summary » |
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PAPS transporter 1 / SLC35B2 C Show summary » |
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PAPS transporter 2 / SLC35B3 C Show summary » |
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YEA / SLC35B4 C Show summary » |
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GDP-Fucose transporter / SLC35C1 C Show summary » |
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OVCOV1 / SLC35C2 Show summary » |
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UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter / SLC35D1 C Show summary »
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HFRC1 / SLC35D2 C Show summary » |
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FRCL1 (Fringe connection-like protein 1 / SLC35D3) Show summary » |
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solute carrier family 35 member E1 / SLC35E1 Show summary » |
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solute carrier family 35 member E2A / SLC35E2A Show summary » |
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solute carrier family 35 member E2B / SLC35E2B Show summary » |
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solute carrier family 35 member E3 / SLC35E3 Show summary » |
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solute carrier family 35 member E4 / SLC35E4 Show summary » |
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solute carrier family 35 member F1 / SLC35F1 Show summary » |
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solute carrier family 35 member F2 / SLC35F2 Show summary » |
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solute carrier family 35 member F3 / SLC35F3 Show summary » |
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solute carrier family 35 member F4 / SLC35F4 Show summary » |
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solute carrier family 35 member F5 / SLC35F5 Show summary » |
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solute carrier family 35 member F6 / SLC35F6 Show summary » |
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solute carrier family 35 member G1 / SLC35G1 Show summary » |
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solute carrier family 35 member G2 / SLC35G2 Show summary » |
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solute carrier family 35 member G3 / SLC35G3 Show summary » |
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solute carrier family 35 member G4 / SLC35G4 Show summary » |
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solute carrier family 35 member G5 / SLC35G5 Show summary » |
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solute carrier family 35 member G6 / SLC35G6 Show summary » |
Database page citation:
SLC35 family of nucleotide sugar transporters. Accessed on 04/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=222.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.