SLC37 family of phosphosugar/phosphate exchangers | Transporters

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SLC superfamily of solute carriers
SLC37 family of phosphosugar/phosphate exchangers

SLC37 family of phosphosugar/phosphate exchangers C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The family of sugar-phosphate exchangers pass particular phosphorylated sugars across intracellular membranes, exchanging for inorganic phosphate. Of the family of sugar phosphate transporters, most information is available on SPX4, the glucose-6-phosphate transporter. This is a 10 TM domain protein with cytoplasmic termini and is associated with the endoplasmic reticulum, with tissue-specific splice variation.

Transporters

SPX1 (Glycerol-3-phosphate transporter / SLC37A1) C Show summary »« Hide summary

Target Id

1165

Nomenclature

Glycerol-3-phosphate transporter

Systematic nomenclature

SLC37A1

Common abbreviation

SPX1

Previous and unofficial names

G3PP | solute carrier family 37 (glycerol-3-phosphate transporter), member 1 | solute carrier family 37 (glucose-6-phosphate transporter), member 1 | solute carrier family 37 (glycerol-3-phosphate transporter)

Genes

SLC37A1 (Hs), Slc37a1 (Mm), Slc37a1 (Rn)

Ensembl ID

ENSG00000160190 (Hs), ENSMUSG00000024036 (Mm), ENSRNOG00000001169 (Rn)

UniProtKB AC

P57057 (Hs)

Bioparadigms SLC Tables

SLC37A1 (Hs)

RESOLUTE

SLC37A1 (Hs)

Endogenous substrates

glucose 6-phosphate

glycerol 3-phosphate

Stoichiometry

Glucose 6-phosphate (in): phosphate (out) [5].

SPX2 (Sugar phosphate exchanger 2 / SLC37A2) C Show summary »« Hide summary

Target Id

1166

Nomenclature

Sugar phosphate exchanger 2

Systematic nomenclature

SLC37A2

Common abbreviation

SPX2

Previous and unofficial names

Genes

SLC37A2 (Hs), Slc37a2 (Mm), Slc37a2 (Rn)

Ensembl ID

ENSG00000134955 (Hs), ENSMUSG00000032122 (Mm), ENSRNOG00000039390 (Rn)

UniProtKB AC

Q8TED4 (Hs), Q9WU81 (Mm)

Bioparadigms SLC Tables

SLC37A2 (Hs)

RESOLUTE

SLC37A2 (Hs)

Endogenous substrates

glucose 6-phosphate

Stoichiometry

Glucose 6-phosphate (in): phosphate (out) [5].

Comment

Acts as a uniporter that transports glucose-6-phosphate from the cytoplasm to endoplasmic reticulum [4]. Involved in metabolic regulation and macrophage inflammation.

SPX3 (Sugar phosphate exchanger 3 / SLC37A3) Show summary »« Hide summary

Target Id	1167
Nomenclature	Sugar phosphate exchanger 3
Systematic nomenclature	SLC37A3
Common abbreviation	SPX3
Previous and unofficial names	solute carrier family 37 (glycerol-3-phosphate transporter), member 3 \| sugar phosphate exchanger 3 \| solute carrier family 37, member 3 \| solute carrier family 37 \| solute carrier family 37 (glycerol-3-phosphate transporter)
Genes	SLC37A3 (Hs), Slc37a3 (Mm), Slc37a3 (Rn)
Ensembl ID	ENSG00000157800 (Hs), ENSMUSG00000029924 (Mm), ENSRNOG00000008725 (Rn)
UniProtKB AC	Q8NCC5 (Hs), Q3TIT8 (Mm)
Bioparadigms SLC Tables	SLC37A3 (Hs)
RESOLUTE	SLC37A3 (Hs)
Stoichiometry	Unknown

SPX4 (Glucose-6-phosphate transporter / SLC37A4) C Show summary »« Hide summary

Target Id

1168

Nomenclature

Glucose-6-phosphate transporter

Systematic nomenclature

SLC37A4

Common abbreviation

SPX4

Previous and unofficial names

Genes

SLC37A4 (Hs), Slc37a4 (Mm), Slc37a4 (Rn)

Ensembl ID

ENSG00000137700 (Hs), ENSMUSG00000032114 (Mm), ENSRNOG00000011361 (Rn)

UniProtKB AC

O43826 (Hs)

Bioparadigms SLC Tables

SLC37A4 (Hs)

RESOLUTE

SLC37A4 (Hs)

Endogenous substrates

glucose 6-phosphate

Inhibitors

S-4048 pIC₅₀ 8.7 [2] - Rat

Stoichiometry

Glucose 6-phosphate (in): phosphate (out) [3].

Comment

Acts as a glucose-6-phosphate/phosphate antiporter [6]. Involved in glycogen metabolism and immune regulation. Multiple polymorphisms have been described for the SLC37A4 gene, some of which associate with a glycogen storage disease [1].

References

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1. Almqvist J, Huang Y, Hovmöller S, Wang DN. (2004) Homology modeling of the human microsomal glucose 6-phosphate transporter explains the mutations that cause the glycogen storage disease type Ib. Biochemistry, 43 (29): 9289-97. [PMID:15260472]

2. Charkoudian LK, Farrella BP, Khosla C. (2012) Natural product inhibitors of glucose-6-phosphate translocase. Medchemcomm, 3 (8): 926-931. DOI: 10.1039/C2MD20008B

3. Chen SY, Pan CJ, Nandigama K, Mansfield BC, Ambudkar SV, Chou JY. (2008) The glucose-6-phosphate transporter is a phosphate-linked antiporter deficient in glycogen storage disease type Ib and Ic. FASEB J, 22 (7): 2206-13. [PMID:18337460]

4. Lai Q, Xu M, Gao Y, Yang Z, Sun L, Liu X. (2026) Structural basis of glucose-6-phosphate transport by human SLC37A2. Nat Struct Mol Biol, 33 (1): 112-122. [PMID:41225050]

5. Pan CJ, Chen SY, Jun HS, Lin SR, Mansfield BC, Chou JY. (2011) SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters. PLoS ONE, 6 (9): e23157. [PMID:21949678]

6. Zhou D, Zhang Y, Chen N, Huang S, Song C, Zhang Z. (2026) Structural basis of G6P/Pi transport and inhibition in SLC37A4. Nat Struct Mol Biol, 33 (1): 123-133. [PMID:41225049]

How to cite this family page

Database page citation:

SLC37 family of phosphosugar/phosphate exchangers. Accessed on 01/04/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=224.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Transporters. Br J Pharmacol. 182: S404-S496.

SLC37 family of phosphosugar/phosphate exchangers C

Overview

Transporters

Further reading

References

How to cite this family page