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SLC37 family of phosphosugar/phosphate exchangers C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The family of sugar-phosphate exchangers pass particular phosphorylated sugars across intracellular membranes, exchanging for inorganic phosphate. Of the family of sugar phosphate transporters, most information is available on SPX4, the glucose-6-phosphate transporter. This is a 10 TM domain protein with cytoplasmic termini and is associated with the endoplasmic reticulum, with tissue-specific splice variation.


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SPX1 (Glycerol-3-phosphate transporter / SLC37A1) C Show summary »

SPX2 (Sugar phosphate exchanger 2 / SLC37A2) C Show summary »

Target Id 1166
Nomenclature Sugar phosphate exchanger 2
Systematic nomenclature SLC37A2
Common abbreviation SPX2
Previous and unofficial names solute carrier family 37 (glycerol-3-phosphate transporter), member 2 | G3PP | cAMP-inducible gene 2 | Slc37a1 | solute carrier family 37 (glucose-6-phosphate transporter), member 2 | solute carrier family 37 (glycerol-3-phosphate transporter)
Genes SLC37A2 (Hs), Slc37a2 (Mm), Slc37a2 (Rn)
Ensembl ID ENSG00000134955 (Hs), ENSMUSG00000032122 (Mm), ENSRNOG00000039390 (Rn)
UniProtKB AC Q8TED4 (Hs), Q9WU81 (Mm)
Bioparadigms SLC Tables SLC37A2 (Hs)
Endogenous substrates
glucose 6-phosphate
Stoichiometry Glucose 6-phosphate (in): phosphate (out) [4].

SPX3 (Sugar phosphate exchanger 3 / SLC37A3) Show summary »

SPX4 (Glucose-6-phosphate transporter / SLC37A4) C Show summary »

Further reading

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How to cite this family page

Database page citation:

SLC37 family of phosphosugar/phosphate exchangers. Accessed on 23/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.