Top ▲

SLC37 family of phosphosugar/phosphate exchangers C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide

The family of sugar-phosphate exchangers pass particular phosphorylated sugars across intracellular membranes, exchanging for inorganic phosphate. Of the family of sugar phosphate transporters, most information is available on SPX4, the glucose-6-phosphate transporter. This is a 10 TM domain protein with cytoplasmic termini and is associated with the endoplasmic reticulum, with tissue-specific splice variation.

Transporters

1168
Click here for help

SPX1 (Glycerol-3-phosphate transporter / SLC37A1) C Show summary »

SPX2 (Sugar phosphate exchanger 2 / SLC37A2) C Show summary »

SPX3 (Sugar phosphate exchanger 3 / SLC37A3) Show summary »

SPX4 (Glucose-6-phosphate transporter / SLC37A4) C Show summary »


Target Id 1168
Nomenclature Glucose-6-phosphate transporter
Systematic nomenclature SLC37A4
Common abbreviation SPX4
Previous and unofficial names G6PT1 | G6PT2 | glucose-6-phosphatase transport protein 1 | glucose-6-phosphate translocase | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | G6PT | G6PT3 | GSD1b | GSD1c | GSD1d | solute carrier family 37 (glucose-6-phosphate transporter)
Genes SLC37A4 (Hs), Slc37a4 (Mm), Slc37a4 (Rn)
Ensembl ID ENSG00000137700 (Hs), ENSMUSG00000032114 (Mm), ENSRNOG00000011361 (Rn)
UniProtKB AC O43826 (Hs)
Bioparadigms SLC Tables SLC37A4 (Hs)
RESOLUTE SLC37A4 (Hs)
Endogenous substrates
glucose 6-phosphate
Inhibitors
S-4048 pIC50 8.7 [2] - Rat
Stoichiometry Glucose 6-phosphate (in): phosphate (out) [3].
Comment Multiple polymorphisms have been described for the SLC37A4 gene, some of which associate with a glycogen storage disease [1].

Further reading

Click here for help

Show »

References

Click here for help

Show »

How to cite this family page

Database page citation:

SLC37 family of phosphosugar/phosphate exchangers. Accessed on 13/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=224.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.