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SLC37 family of phosphosugar/phosphate exchangers C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The family of sugar-phosphate exchangers pass particular phosphorylated sugars across intracellular membranes, exchanging for inorganic phosphate. Of the family of sugar phosphate transporters, most information is available on SPX4, the glucose-6-phosphate transporter. This is a 10 TM domain protein with cytoplasmic termini and is associated with the endoplasmic reticulum, with tissue-specific splice variation.


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SPX1 (Glycerol-3-phosphate transporter / SLC37A1) C Show summary »

SPX2 (Sugar phosphate exchanger 2 / SLC37A2) C Show summary »

SPX3 (Sugar phosphate exchanger 3 / SLC37A3) Show summary »

SPX4 (Glucose-6-phosphate transporter / SLC37A4) C Show summary »

Target Id 1168
Nomenclature Glucose-6-phosphate transporter
Systematic nomenclature SLC37A4
Common abbreviation SPX4
Previous and unofficial names G6PT1 | G6PT2 | glucose-6-phosphatase transport protein 1 | glucose-6-phosphate translocase | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | G6PT | G6PT3 | GSD1b | GSD1c | GSD1d | solute carrier family 37 (glucose-6-phosphate transporter)
Genes SLC37A4 (Hs), Slc37a4 (Mm), Slc37a4 (Rn)
Ensembl ID ENSG00000137700 (Hs), ENSMUSG00000032114 (Mm), ENSRNOG00000011361 (Rn)
UniProtKB AC O43826 (Hs)
Bioparadigms SLC Tables SLC37A4 (Hs)
Endogenous substrates
glucose 6-phosphate
S-4048 pIC50 8.7 [2] - Rat
Stoichiometry Glucose 6-phosphate (in): phosphate (out) [3].
Comment Multiple polymorphisms have been described for the SLC37A4 gene, some of which associate with a glycogen storage disease [1].

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How to cite this family page

Database page citation:

SLC37 family of phosphosugar/phosphate exchangers. Accessed on 13/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.