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SLC41 family of divalent cation transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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By analogy with bacterial orthologues, this family is probably magnesium transporters. The prokaryote orthologue, MgtE, is responsible for uptake of divalent cations, while the heterologous expression studies of mammalian proteins suggest Mg2+ efflux [3], possibly as a result of co-expression of particular protein partners (see [4]). Topological modelling suggests 10 TM domains with cytoplasmic C- and N- termini.

Transporters

1197
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MgtE (Solute carrier family 41 member 1 / SLC41A1) C Show summary »

Solute carrier family 41 member 2 / SLC41A2 C Show summary »

Solute carrier family 41 member 3 / SLC41A3 Show summary »


Target Id 1197
Nomenclature Solute carrier family 41 member 3
Systematic nomenclature SLC41A3
Previous and unofficial names SLC41A1-L2 | solute carrier family 41
Genes SLC41A3 (Hs), Slc41a3 (Mm), Slc41a3 (Rn)
Ensembl ID ENSG00000114544 (Hs), ENSMUSG00000030089 (Mm), ENSRNOG00000045821 (Rn)
UniProtKB AC Q96GZ6 (Hs), Q921R8 (Mm), Q3SWT5 (Rn)
Bioparadigms SLC Tables SLC41A3 (Hs)
Stoichiometry Unknown

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References

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How to cite this family page

Database page citation:

SLC41 family of divalent cation transporters. Accessed on 07/12/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=230.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.