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SLC45 family of putative sugar transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Members of the SLC45 family remain to be fully characterised. SLC45A1 was initially identified in the rat brain, particularly predominant in the hindbrain, as a proton-associated sugar transport, induced by hypercapnia [3]. The protein is predicted to have 12TM domains, with intracellular termini. The SLC45A2 gene is thought to encode a transporter protein that mediates melanin synthesis. Mutations in SLC45A2 are a cause of oculocutaneous albinism type 4 (e.g. [2]), and polymorphisms in this gene are associated with variations in skin and hair color (e.g. [1]).

Transporters

1211
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Proton-associated sugar transporter A / SLC45A1 C Show summary »

Membrane-associated transporter protein / SLC45A2 Show summary »

Solute carrier family 45 member 3 / SLC45A3 Show summary »


Target Id 1211
Nomenclature Solute carrier family 45 member 3
Systematic nomenclature SLC45A3
Previous and unofficial names IPCA-2 | IPCA-6 | IPCA-8 | PCANAP2 | PCANAP6 | PCANAP8 | prostein | prostate cancer associated protein 2 | prostate cancer associated protein 6 | prostate cancer associated protein 8 | solute carrier family 45 member 3 | PRST | solute carrier family 45
Genes SLC45A3 (Hs), Slc45a3 (Mm), Slc45a3 (Rn)
Ensembl ID ENSG00000158715 (Hs), ENSMUSG00000026435 (Mm), ENSRNOG00000007591 (Rn)
UniProtKB AC Q96JT2 (Hs), Q8K0H7 (Mm)
Bioparadigms SLC Tables SLC45A3 (Hs)

Solute carrier family 45 member 4 / SLC45A4 Show summary »

Further reading

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References

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How to cite this family page

Database page citation:

SLC45 family of putative sugar transporters. Accessed on 07/12/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=234.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.