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SLCO family of organic anion transporting polypeptides C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The SLCO superfamily is comprised of the organic anion transporting polypeptides (OATPs). The 11 human OATPs are divided into 6 families and ten subfamilies based on amino acid identity. These proteins are located on the plasma membrane of cells throughout the body. They have 12 TM domains and intracellular termini, with multiple putative glycosylation sites. OATPs mediate the sodium-independent uptake of a wide range of amphiphilic substrates, including many drugs and toxins. Due to the multispecificity of these proteins, this guide lists classes of substrates and inhibitors for each family member. More comprehensive lists of substrates, inhibitors, and their relative affinities may be found in the review articles listed below.

Transporters

1219
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OATP1A2 / SLCO1A2 C Show summary »


Target Id 1219
Nomenclature OATP1A2
Systematic nomenclature SLCO1A2
Previous and unofficial names SLC21A3 | OATP | OATP-A | solute carrier family 21 (organic anion transporter), member 3 | solute carrier organic anion transporter family, member 1A2
Genes SLCO1A2 (Hs)
Ensembl ID ENSG00000084453 (Hs)
UniProtKB AC P46721 (Hs)
Bioparadigms SLC Tables SLCO1A2 (Hs)
Endogenous substrates
PGE2
bilirubin
bile acids
steroid conjugates
thyroid hormones
Substrates
deltorphin II
rosuvastatin
bromsulphthalein
talinolol
microcystin-LR [4]
fexofenadine
ouabain
antibiotics
anticancer drugs
beta blockers
fluoroquinolones
HIV protease inhibitors
Inhibitors
rifamycin SV pKi 5.0 [10]
rifampicin pKi 4.3 [10]
naringin [1]
Labelled ligands
[3H]DPDPE
[3H]BSP
[3H]estrone-3-sulphate
Comment Although rat and mouse OATP1A4 are considered the orthologs of human OATP1A2 we do not cross-link to gene or protein databases for these since in reality there are five genes in rodents that arose through gene duplication in this family and it is not clear which one of these is the "true" ortholog.

OATP1B1 / SLCO1B1 C Show summary »

OATP1B3 / SLCO1B3 C Show summary »

OATP1C1 / SLCO1C1 C Show summary »

OATP2A1 / SLCO2A1 C Show summary »

OATP2B1 / SLCO2B1 C Show summary »

OATP3A1 / SLCO3A1 C Show summary »

OATP4A1 / SLCO4A1 C Show summary »

OATP4C1 / SLCO4C1 C Show summary »

OATP5A1 / SLCO5A1 Show summary »

OATP6A1 / SLCO6A1 Show summary »

Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.