Top ▲

SLCO family of organic anion transporting polypeptides C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide

The SLCO superfamily is comprised of the organic anion transporting polypeptides (OATPs). The 11 human OATPs are divided into 6 families and ten subfamilies based on amino acid identity. These proteins are located on the plasma membrane of cells throughout the body. They have 12 TM domains and intracellular termini, with multiple putative glycosylation sites. OATPs mediate the sodium-independent uptake of a wide range of amphiphilic substrates, including many drugs and toxins. Due to the multispecificity of these proteins, this guide lists classes of substrates and inhibitors for each family member. More comprehensive lists of substrates, inhibitors, and their relative affinities may be found in the review articles listed below.

Transporters

1222
Click here for help

OATP1A2 / SLCO1A2 C Show summary »

OATP1B1 / SLCO1B1 C Show summary »

OATP1B3 / SLCO1B3 C Show summary »

OATP1C1 / SLCO1C1 C Show summary »


Target Id 1222
Nomenclature OATP1C1
Systematic nomenclature SLCO1C1
Previous and unofficial names OATP1 | OATP-F | SLC21A14 | solute carrier family 21 (organic anion transporter), member 14 | BBB-specific anion transporter type 1 | blood-brain barrier specific anion transporter | Bsat1 | Oatp14 | Oatp2 | solute carrier organic anion transporter family member 1C1 | thyroxine transporter | solute carrier organic anion transporter family, member 1C1 | solute carrier organic anion transporter family
Genes SLCO1C1 (Hs), Slco1c1 (Mm), Slco1c1 (Rn)
Ensembl ID ENSG00000139155 (Hs), ENSMUSG00000030235 (Mm), ENSRNOG00000009740 (Rn)
UniProtKB AC Q9NYB5 (Hs), Q9ERB5 (Mm), Q9EPZ7 (Rn)
Bioparadigms SLC Tables SLCO1C1 (Hs)
Endogenous substrates
steroid conjugates
thyroid hormones
Substrates
bromsulphthalein
statins
Inhibitors
DPDPE
probenecid
taurocholic acid
Labelled ligands
[3H]BSP
[125I]thyroxine
[3H]estrone-3-sulphate

OATP2A1 / SLCO2A1 C Show summary »

OATP2B1 / SLCO2B1 C Show summary »

OATP3A1 / SLCO3A1 C Show summary »

OATP4A1 / SLCO4A1 C Show summary »

OATP4C1 / SLCO4C1 C Show summary »

OATP5A1 / SLCO5A1 Show summary »

OATP6A1 / SLCO6A1 Show summary »

Further reading

Click here for help

Show »

References

Click here for help

Show »

NC-IUPHAR subcommittee and family contributors

Show »

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.