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SLCO family of organic anion transporting polypeptides C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The SLCO superfamily is comprised of the organic anion transporting polypeptides (OATPs). The 11 human OATPs are divided into 6 families and ten subfamilies based on amino acid identity. These proteins are located on the plasma membrane of cells throughout the body. They have 12 TM domains and intracellular termini, with multiple putative glycosylation sites. OATPs mediate the sodium-independent uptake of a wide range of amphiphilic substrates, including many drugs and toxins. Due to the multispecificity of these proteins, this guide lists classes of substrates and inhibitors for each family member. More comprehensive lists of substrates, inhibitors, and their relative affinities may be found in the review articles listed below.

Transporters

1223
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OATP1A2 / SLCO1A2 C Show summary »

OATP1B1 / SLCO1B1 C Show summary »

OATP1B3 / SLCO1B3 C Show summary »

OATP1C1 / SLCO1C1 C Show summary »

OATP2A1 / SLCO2A1 C Show summary »


Target Id 1223
Nomenclature OATP2A1
Systematic nomenclature SLCO2A1
Previous and unofficial names PGT | SLC21A2 | prostaglandin transporter | solute carrier family 21 (prostaglandin transporter) member 2 | solute carrier organic anion transporter family member 2A1 | MATR1 | solute carrier organic anion transporter family, member 2A1 | solute carrier organic anion transporter family
Genes SLCO2A1 (Hs), Slco2a1 (Mm), Slco2a1 (Rn)
Ensembl ID ENSG00000174640 (Hs), ENSMUSG00000032548 (Mm), ENSRNOG00000009005 (Rn)
UniProtKB AC Q92959 (Hs), Q9EPT5 (Mm), Q00910 (Rn)
Bioparadigms SLC Tables SLCO2A1 (Hs)
Endogenous substrates
eicosanoids
prostaglandins
Substrates
synthetic prostaglandin derivatives
Inhibitors
bromocresol green pKi 5.4 (Inhibition of PGF uptake in PGT-expressing HeLa cells) [6] - Rat
bromsulphthalein pKi 5.2 (Inhibition of PGF uptake in PGT-expressing HeLa cells) [6] - Rat
Labelled ligands
[3H]PGE2 (Binding) [2]
Comment Other inhibitors include NSAIDs

OATP2B1 / SLCO2B1 C Show summary »

OATP3A1 / SLCO3A1 C Show summary »

OATP4A1 / SLCO4A1 C Show summary »

OATP4C1 / SLCO4C1 C Show summary »

OATP5A1 / SLCO5A1 Show summary »

OATP6A1 / SLCO6A1 Show summary »

Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.