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SLCO family of organic anion transporting polypeptides C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The SLCO superfamily is comprised of the organic anion transporting polypeptides (OATPs). The 11 human OATPs are divided into 6 families and ten subfamilies based on amino acid identity. These proteins are located on the plasma membrane of cells throughout the body. They have 12 TM domains and intracellular termini, with multiple putative glycosylation sites. OATPs mediate the sodium-independent uptake of a wide range of amphiphilic substrates, including many drugs and toxins. Due to the multispecificity of these proteins, this guide lists classes of substrates and inhibitors for each family member. More comprehensive lists of substrates, inhibitors, and their relative affinities may be found in the review articles listed below.

Transporters

1224
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OATP1A2 / SLCO1A2 C Show summary »

OATP1B1 / SLCO1B1 C Show summary »

OATP1B3 / SLCO1B3 C Show summary »

OATP1C1 / SLCO1C1 C Show summary »

OATP2A1 / SLCO2A1 C Show summary »

OATP2B1 / SLCO2B1 C Show summary »


Target Id 1224
Nomenclature OATP2B1
Systematic nomenclature SLCO2B1
Previous and unofficial names SLC21A9 | solute carrier family 21 (organic anion transporter), member 9 | moat1 | multispecific organic anion transporter 1 | organic anion transporter moatp1 | solute carrier organic anion transporter family member 2B1 | OATP-B | solute carrier organic anion transporter family, member 2B1 | solute carrier organic anion transporter family
Genes SLCO2B1 (Hs), Slco2b1 (Mm), Slco2b1 (Rn)
Ensembl ID ENSG00000137491 (Hs), ENSMUSG00000030737 (Mm), ENSRNOG00000017976 (Rn)
UniProtKB AC O94956 (Hs), Q8BXB6 (Mm), Q9JHI3 (Rn)
Bioparadigms SLC Tables SLCO2B1 (Hs)
Endogenous substrates
T4
dehydroepiandrosterone sulphate
estrone-3-sulphate
Substrates
telmisartan
glibenclamide
amiodarone
bosentan
bromsulphthalein
talinolol
aliskiren
fexofenadine
statins
Inhibitors
erlotinib pKi 6.3 [7]
verlukast pKi 5.6 [7]
glibenclamide
gemfibrozil
rifamycin SV
sildenafil [9]
Labelled ligands
[3H]BSP
[3H]estrone-3-sulphate
Comment Other inhibitors include glitazones and citrus juices

OATP3A1 / SLCO3A1 C Show summary »

OATP4A1 / SLCO4A1 C Show summary »

OATP4C1 / SLCO4C1 C Show summary »

OATP5A1 / SLCO5A1 Show summary »

OATP6A1 / SLCO6A1 Show summary »

Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.