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SLCO family of organic anion transporting polypeptides C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The SLCO superfamily is comprised of the organic anion transporting polypeptides (OATPs). The 11 human OATPs are divided into 6 families and ten subfamilies based on amino acid identity. These proteins are located on the plasma membrane of cells throughout the body. They have 12 TM domains and intracellular termini, with multiple putative glycosylation sites. OATPs mediate the sodium-independent uptake of a wide range of amphiphilic substrates, including many drugs and toxins. Due to the multispecificity of these proteins, this guide lists classes of substrates and inhibitors for each family member. More comprehensive lists of substrates, inhibitors, and their relative affinities may be found in the review articles listed below.


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OATP1A2 / SLCO1A2 C Show summary »

OATP1B1 / SLCO1B1 C Show summary »

OATP1B3 / SLCO1B3 C Show summary »

OATP1C1 / SLCO1C1 C Show summary »

OATP2A1 / SLCO2A1 C Show summary »

OATP2B1 / SLCO2B1 C Show summary »

OATP3A1 / SLCO3A1 C Show summary »

Target Id 1225
Nomenclature OATP3A1
Systematic nomenclature SLCO3A1
Previous and unofficial names OATP-D | SLC21A11 | solute carrier family 21 (organic anion transporter), member 11 | organic anion-transporting polypeptide D | prostaglandin transporter subtype 2 | sodium-independent organic anion transporter D | solute carrier organic anion transporter family member 3A1 | Anr1 | MJAM | solute carrier organic anion transporter family, member 3A1 | solute carrier organic anion transporter family
Genes SLCO3A1 (Hs), Slco3a1 (Mm), Slco3a1 (Rn)
Ensembl ID ENSG00000176463 (Hs), ENSMUSG00000025790 (Mm), ENSRNOG00000032798 (Rn)
UniProtKB AC Q9UIG8 (Hs), Q8R3L5 (Mm), Q99N02 (Rn)
Endogenous substrates
thyroid hormones
Labelled ligands

OATP4A1 / SLCO4A1 C Show summary »

OATP4C1 / SLCO4C1 C Show summary »

OATP5A1 / SLCO5A1 Show summary »

OATP6A1 / SLCO6A1 Show summary »

Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.