Top ▲

Carboxylases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide

The carboxylases allow the production of new carbon-carbon bonds by introducing HCO3- or CO2 into target molecules. Two groups of carboxylase activities, some of which are bidirectional, can be defined on the basis of the cofactor requirement, making use of biotin (EC 6.4.1.-) or vitamin K hydroquinone (EC 4.1.1.-).

Enzymes

1267
Click here for help

Complexes

PCCA,PCCB (Propionyl-CoA carboxylase ) C Show summary »

Enzymes and Subunits

PC (Pyruvate carboxylase) C Show summary »

ACC1 (Acetyl-CoA carboxylase 1) C Show summary » More detailed page go icon to follow link

ACC2 (Acetyl-CoA carboxylase 2) C Show summary » More detailed page go icon to follow link

PCCA (Propionyl-CoA carboxylase α subunit) Show summary »

PCCB (Propionyl-CoA carboxylase β subunit) Show summary »


Target Id 1267
Nomenclature Propionyl-CoA carboxylase β subunit
Common abbreviation PCCB
Previous and unofficial names PCCβ | PCCase subunit beta | propanoyl-CoA:carbon dioxide ligase subunit beta | propionyl-CoA carboxylase beta chain, mitochondrial | propionyl Coenzyme A carboxylase | propionyl-CoA carboxylase beta subunit
Complexes PCCA,PCCB (Propionyl-CoA carboxylase )
Genes PCCB (Hs), Pccb (Mm), Pccb (Rn)
Ensembl ID ENSG00000114054 (Hs), ENSMUSG00000032527 (Mm), ENSRNOG00000015869 (Rn)
UniProtKB AC P05166 (Hs), Q99MN9 (Mm), P07633 (Rn)

GGCX (γ-Glutamyl carboxylase) C Show summary » More detailed page go icon to follow link

Comments

Click here for help

Show »

References

Click here for help

Show »

How to cite this family page

Database page citation:

Carboxylases. Accessed on 04/12/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=255.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.